242-Spatiotemporal Atlas of Early Human Heart Development
The article details a comprehensive study that utilized spatial and single-cell transcriptomics alongside imaging to map the cellular and molecular landscape of the developing human heart between 5.5 and 14 postconceptional weeks. Researchers created a high-resolution transcriptomic map, identifying 31 coarse-grained and 72 fine-grained cell states organized into functional niches, and specifically explored the formation of the cardiac pacemaker-conduction system (CPCS), heart valves, and autonomic innervation. A key finding was the identification of a resident neuroendocrine chromaffin cell…
The skinny
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