1245-Mapping the Aging Mammary Landscape
This research paper presents a comprehensive single-cell atlas of the aging mouse mammary gland, detailing how cellular environments transform over time. By utilizing scRNA-seq and snATAC-seq technologies, the study identifies significant compositional shifts across epithelial, immune, and stromal cell populations. The findings reveal that aging triggers epigenetic and transcriptomic rewiring that mirrors signatures typically found in breast cancer. Specifically, aged tissues show an expansion of pro-inflammatory T cells and a transition of fibroblasts into states that resemble…
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