1698-ISR Drives Lung Cancer Lineage Reprogramming

Paper Talk · Oct 22, 2026 · 25m

The research demonstrates that the integrated stress response acts as a crucial driver of lung adenocarcinoma progression, directing tumor cells toward aggressive, undifferentiated, and high-plasticity states through key signaling axes like p-eIF2α and ATF4. By utilizing advanced single-cell technologies and mouse models, the findings reveal that this stress-adaptation mechanism promotes intratumor heterogeneity and lineage reprogramming, whereas inhibiting the pathway suppresses tumor expansion and alters cellular evolutionary trajectories. Furthermore, disruption of these stress pathways…