549-IFNγ-Metabolic Control of Lymphatic Metastasis
This research identifies IFNγ as a critical regulator that prevents the spread of melanoma by altering the metabolism of lymphatic vessels. The study demonstrates that while intratumoral lymphangiogenesis typically facilitates metastasis, high levels of IFNγ from active immune cells force these vessels into a mature, stagnant state. This process occurs because IFNγ suppresses mitochondrial respiration and oxidative phosphorylation within lymphatic cells, effectively starving the energy source required for their growth. By inhibiting this metabolic reprogramming, the immune system restricts an…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.