757-scHiCAR: Trimodal Single-Cell Profiling

Paper Talk · Apr 7, 2026 · 19m

The paper introduce scHiCAR, a high-throughput and cost-effective multiomic technology designed to simultaneously profile the transcriptome, epigenome, and 3D genome within individual cells. This plate-based method utilizes combinatorial barcoding to integrate data on mRNA, open chromatin, and chromosome conformation, specifically enriching long-range interactions anchored at cis-regulatory elements. Researchers successfully applied this tool to over 1.6 million mouse brain cells, revealing complex gene-regulatory landscapes across 22 distinct cell types. To enhance data analysis, the authors…