475-DNA-Diffusion:Design Cell-Specific Regulatory Elements
The paper details the development of DNA-Diffusion, a generative artificial intelligence framework designed to engineer synthetic DNA regulatory elements. By utilizing a diffusion model trained on large-scale genomic data, researchers can now create compact sequences that dictate how genes are turned on or off in specific cell types. These lab-designed elements were shown to be functionally superior to natural sequences, offering higher activity and better precision across different tissues. The study validated these findings using large-scale screening and successfully edited a…
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