1155-Renoir: Charting Spatial Ligand-Target Activity

Paper Talk · Jun 19, 2026 · 24m

This research introduces Renoir, a sophisticated computational framework designed to map cell-cell communication within the spatial architecture of tissues. By integrating single-cell transcriptomics with spatial data, Renoir tracks how ligands influence downstream target genes across specific neighborhood niches. The system outperforms existing methods by reducing false positives through the inclusion of receptor expression and spatial proximity in its activity scoring. Researchers successfully applied Renoir to diverse contexts, including mouse brain structures, breast cancer…