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540-POCKET: Conformal Bioelectronics for Whole-Organ Therapy

This research introduces POCKET, a novel bioelectronic patch designed for the high-precision delivery of therapeutics directly into internal organs. Utilizing a flexible kirigami-structured design, the device achieves superior conformality, allowing it to wrap seamlessly around organs with complex or irregular shapes. The patch utilizes wireless powering to facilitate electro-transfection, a method that effectively delivers genetic material or drugs while avoiding the harmful side effects of systemic circulation. Experimental results show that the device can successfully restore ovarian…

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