788-The MSK-50K Pan-Cancer Resource of Driver Alterations
The paper details the MSK-50K cohort, a massive clinico-genomic study analyzing over 54,000 tumors across 448 cancer subtypes to map tissue-specific driver alterations. Researchers identified 164 new cancer hotspots and discovered that one-third of drivers occur in non-canonical contexts, often displaying unique biological features like increased subclonality and later emergence. The study highlights how tissue type and clinical context—including age of onset and genetic ancestry—influence the functional roles of mutations. By examining clonality, zygosity, and co-mutation patterns, the…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.