1664-Integrated Signatures of Mutational in Prostate Cancer
The research from the Pan Prostate Cancer Group details a comprehensive study of nearly 1,000 whole-genome sequences to map the mutational processes driving prostate cancer. Researchers established a novel framework of eight integrated mutational footprints (IMFs) by combining data from single-base substitutions, structural variants, and copy-number alterations. These footprints reveal how factors like androgen receptor signaling, replication stress, and DNA repair deficiencies shape the tumor's genetic landscape. Crucially, the study identifies specific IMFs that act as clinical biomarkers…
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