1501-Dusp5&Zfp219 to Rejuvenate Aged Antitumor Immunity
This research identifies Dusp5 and Zfp219 as two key genetic regulators that drive T cell exhaustion and failure in older cancer patients. Using CRISPR screens in mouse models, scientists discovered that removing these specific genes helps CD8+ T cells regain their ability to fight tumors within the harsh environment of an aging body. Deleting Dusp5 improves immune responses across all ages by boosting T cell division through the ERK signaling pathway, whereas removing Zfp219 specifically rescues the immune function of aged cells by restoring granzyme production. High levels of ZNF219 in…
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