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The dose escalation that flipped gaboxadol into psychosis
A chemist turns a fly agaric molecule into a sleep drug, but dose escalation exposes a psychiatric flip that could undo the whole program.
The dose escalation that flipped gaboxadol into psychosis
In this episode, we follow the development of gaboxadol from Povl Krogsgaard-Larsen’s self‑experiment to large clinical trials, tracing how a molecule derived from Amanita muscaria behaved across animals and humans and raising the question: at what dose does a promising sleep drug become psychiatric hazard?
Person: Povl Krogsgaard-Larsen
Person: Marike Lancel
Company: Lundbeck; Merck
Compound…
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