872-Spatiotemporal Atlas of Human Maternal-Fetal Interface

Paper Talk · Apr 29, 2026 · 21m

This study presents a spatially resolved single-cell atlas of the human maternal–fetal interface, spanning from early gestation to full term. By integrating single-nucleus multiomics with high-resolution spatial transcriptomics, researchers identified diverse cell types and the gene regulatory networks that dictate trophoblast differentiation. The authors propose a toggle switch model where specific transcription factors enforce unique cellular identities while actively suppressing alternative fates. Furthermore, the research maps intercellular communication within distinct anatomical niches…