Latest / Ageless and Timeless Podcast® / Ross Pelton, Scientific Director for Essential Formulas, Inc

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Ross Pelton, Scientific Director for Essential Formulas, Inc · Ageless and Timeless Podcast®

0:09
Good morning everyone. This is Michelle Hughes from Ageless and Timeless. Today I
0:15
am very excited to introduce you to a guest who has a very very recognized
0:22
name, and you'll maybe some of you have heard of him. His name
0:25
is Ross Pelton. He's called sometimes by the nickname the natural Pharmacist, and
0:31
we'll be talking about that in a moment. He's not an allopathic pharmacist anymore.
0:36
He's a longevity pharmacist and he's internationally known for his work with twelve books
0:44
and very prolific of course, and then his most recent work on the drug
0:50
that is a longevity drug called rapamson. So today we're going to try to
0:55
limit ourselves to the discussion of rapamison and the associated terms that we'll be going
1:02
through that will help you to understand why rappamsin is the anti aging drug of
1:07
the century and why Ross has become so interested in that understanding of that drug
1:15
from the science standpoint. I think it's really cute because Ross says he's bilingual.
1:21
He speaks English and science, so you'll know today that you're going to
1:25
be getting a very science based discussion. This is not anything to do with
1:33
just a pie in the sky. This is real science, so be prepared.
1:38
Okay, welcome Ross, Hi Michelle. It's really an honor to be
1:42
with you and Ages and Timeless, so thanks very much for the invitation.
1:45
Well, you are quite the role model for all of us, if you
1:49
don't mind me staying a little bit about you, just to start before we
1:53
start. But you know, you probably can't tell by looking at Ross to
1:57
my viewers, but he is eighty in his eighties. I don't know exactly
2:02
what number, but that's okay. He is the picture of health. And
2:09
it wasn't always that way, right Ross, He was you know, a
2:14
typical sa d a sad diet in his earlier days. And he tells the
2:20
story that he was walking by down in southern California. He was walking by
2:25
a building and he heard some music coming out of the building and he peeked
2:31
in and he saw these thing called yoga, and he was so intrigued by
2:37
the positions and the and the benefits that the people seemed to be getting that
2:43
he started to basically, you know, look at that as an alternative for
2:47
his own program. And well, out went the white bread and the milk
2:53
and all of that. That he was carrying at the time, and in
2:55
came the Knew Ross, which is the pharmacist of healthy living. So is
3:04
that a pretty good summary Ross, You bet, Michelle, that's a good
3:07
overview. But along with the commitment to regular exercise and healthy food, my
3:13
introduction to yoga got me introduced to people who are reading health books and health
3:19
newsletters and health magazines. And with my background in science, even though I
3:22
knew nothing about health, I just started to absorb this information about health related
3:29
things in the literature and it all made sense to me, and it's been
3:32
making sense to me ever since. You know, Ross, It's interesting because
3:38
I am also guilty of the same kind of entree into the wellness world.
3:45
It was a little different, but I did early on reading all the books
3:49
of Adel Davis, all the books of Sandy Shaw and Dirk Pearson and the
3:53
Life Extension. I'm sure those are probably some of the books that you were
3:58
reading at the same time or maybe a little bit earlier than me. But
4:00
you know, similar to how we both came to where we are today.
4:05
Yeah, that's true. And so this stuff was so interesting to me,
4:11
and when I got introduced to it, I just kept absorbing it like a
4:15
sponge, and then I started to write about it, and then I started
4:18
to teach about it, and I've been doing that for decades and decades now,
4:24
So tell us let's let's let's dive deep. Okay, So all the
4:29
people that watch my podcast are one common denominator, we could say for everyone,
4:34
and that is a curiosity about living a healthier and higher quality life,
4:42
so being the best version of yourself. And so we are we're talking to
4:47
the right audience to hear about your discoveries. And I want people here to
4:53
understand that there are a lot of terms that you're going to hear today that
4:57
my viewers and I didn't really know about until I started reading Ross's book and
5:02
I attended the American Academy of Anti Aging their conventions and all throughout the literature
5:12
and the innovative technology that's occurring today is this discussion of rapamisin met foreman and
5:21
of course the synonymous with those two drugs are the discussion of mtur and autopogy.
5:33
So we're going to start with defining terms, Ross, if you don't
5:36
mind, So let's start with what is rapamcin. Let's get to the kind
5:43
of the first stage of our understanding. So I'll start with rapamise and I
5:46
just I'll make one comment to you our viewers about what you just kind of
5:50
covered there about new terms and so forth. Anytime anybody wants to be good
5:56
at anything, whether it's becoming a lawyer or a doctor or whatever, you
6:01
have to focus on the language of that particular profession and you have to fill
6:06
up a whole new vocabulary. So it's the same thing with health. If
6:11
people really want to be healthy, there's things you have to study and learn,
6:15
and if you speak English you're capable of doing this. There would be
6:18
new terms, but after you've become exposed to them three or four or five
6:23
times and somebody starts to explain to you what they are and why they're important,
6:28
it logs in your brain and you start to become familiar with that and
6:31
it becomes part of your own story. And so that's what I like to
6:35
do. You'd mentioned I'm bilingual. I speak English and science, but I
6:40
can talk about the science in a way that normal, non scientific people can
6:45
understand it. So that background, let's start with rapamisin. Rapamicin is a
6:50
drug that was discovered as the result of a group of Canadian scientists back in
6:57
the nineteen sixties who took a scientific expedition to Easter Island, and the goal
7:02
of that expedition was to see if they could find sources of new anti fungal
7:08
or antibiotic drugs. So they took a lot of soil samples from around Easter
7:13
Island, and one of the soil samples when they got back to their labs,
7:17
contained a substance that was naturally made by a species of soil bacteria.
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So this is a compound made naturally in nature, it's not some foreign compound
7:29
that a drug company created. And because this compound was discovered on Easter Island,
7:35
it was named rapamycin, which is based on the indigenous people's name for
7:43
Easter Island, which is Rapaanui. So that's why they chose the name rapamsin
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and name of this drug that originally was found to have very strong antifungal properties.
7:56
So it was initially developed as an antifungal drug, and Telley discovered that
8:01
it suppresses the immune system, so all the research stopped and then a number
8:07
of years later, the FDA approved this drug for people getting kidney transplants because
8:13
people with organ transplants need to be taking immune suppress and drugs all the time.
8:20
And then in the early two thousands, rapamycin was approved by the FDA
8:24
for several solid tumor cancers. These FDA approvals have actually been a hindrance to
8:33
getting it accepted as a life extension drug because doctors don't usually write prescriptions for
8:41
chemotherapy or an organ transplant drug for those of us that are life extension enthusiasts.
8:46
But the real critical breakthrough came in a study conducted by doctor Joan Mannik.
8:54
She was working at the big drug company called Novartis, and she had
8:58
the enviable job of being able to research anything that she wanted to research.
9:03
So she was interested in aging and she chose the drug rap of misin,
9:09
and she conducted what is a landmark clinical trial. It's the first major human
9:13
clinical trial with rapamcin. She selected a group of elderly people aged sixty five
9:20
and older, divided them into four groups. There was a placebo group and
9:26
then one group got one milligram of a wrap of myson like drug once daily.
9:31
One group took five milligrams once a week that another fourth group took twenty
9:37
milligrams once a week. So there were four groups going for a number of
9:43
weeks, and at the end of that time, everybody stopped, whether it
9:46
was the placebo or one of the doses of the drugs, there was a
9:48
wash out period, and at the end of the wash out period, she
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subjected all of the volunteers to the seasonal flu vaccine, then did blood work
9:58
and measured how their immune system responded to that challenge. The people taking the
10:05
rapimcin drug five milligrams once a week got a twenty percent boost to the effectiveness
10:11
of their immune system. Now, if you're an elderly person and you can
10:16
get a twenty percent increase in your immune system, excuse me, that's a
10:22
really big deal. So this is the first study that showed that taking rapimizon
10:26
episodically rather than daily, causes some significant health benefits m HM. So Ros's
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question is that the only human study that's been done on rapimis into date.
10:41
No, there's multiple studies, not a lot of them. Most of the
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studies have been done in animals, but there's so much interested in drug.
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A number of other human trials are ongoing and more are being designed. But
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in animal studies every single age related disease responds favor, believe. So let
11:01
me talk a little bit more about the other terms in the title of my
11:03
book, m tour and atoplogy, and I'll define those and that will give
11:09
me the ability to explain the mechanism of how raprimisin works as an anti aging
11:15
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12:11
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12:16
It's like a triage, right, We're talking mtur autophagy and rapamisin. So
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maybe just doing define mchor and autophogy first so people understand what we're where we're
12:28
going with, right, So rapamisin is the drug we already discovered. And
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to discuss that, anitour was discovered by David Sabatini back in nineteen ninety six.
12:45
When rappamcin gets absorbed across the celluar membrane goes inside the cell, it
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binds to a protein actually an enzyme. David Sabatini named this rapamicin site of
12:58
attachment an m tour, which stands for the mechanistic target of rapamycin. So
13:05
that's where mTOR got its name. It's where rapamycin binds two when it enters
13:11
a cell. So now what does this m toor do? It turns out
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that mTOR is a master signaling compound in all cells and even when nutrients are
13:22
available to a cell, m TOR sends out signals. It says, use
13:28
these nutrients to build and grow, make new proteins, make new enzyme,
13:33
build new cellular components. So m TOR is the signal to recognize when nutrients
13:39
are available so the body can use these nutrients to build and grow. The
13:45
other side of the equation is this term called autophogy, and a Japanese scientist
13:50
won the Nobel Prize for his discovery of autoplogy in twenty sixteen, so it's
13:56
relatively recent. Topogy gets activated when no nutrients are available to the cell,
14:05
so there are no nutrients coming in, Atopogy gets activated and it does several
14:11
things. It breaks down old dysfunctional cellular components proteins and enzymes and so forth,
14:20
and either gets them out of the system. So it's a detoxification process
14:24
for every cell in your body. But oftentimes it will reutilize the components.
14:31
For example, if it's breaking out an enzyme or protein, it'll reutilize the
14:35
amino acids to build a healthy new protein or a healthy new enzyme. So
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atopogy, in addition to being key for detoxification, it's also the process for
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rebuilding and renewing your body on a constant basis, and that's a critically important
14:50
part of health and long term survival. And I use the example of a
14:58
car that has a flaw tire. You can't put the new tire on until
15:03
you get the old tire off, and that's the same way with old damage
15:09
misfunctioning proteins and enzymes. Even though they don't work very well, they're broken
15:15
down over time, they're still in place, occupying a space and not allowing
15:20
a healthy new protein to come in and take over. So atopogy has to
15:24
function to break down these old proteins and enzymes so that you can build healthy
15:30
new ones. And for most of human evolution, hundreds and hundreds of thousands
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of years. In fact, we actually go back millions of years, we
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go before Homo sapiens. But as humankind was evolving over time, m tour
15:46
and atopogy were in balance. These days they're out of balance with most people
15:52
alive. And why and why is that? Ros? Why? That's what
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I want to talk about and get people to under stand why most people are
16:00
so out of balance between their autophagy and their mTOR. In fact, this
16:06
is such a critically important point, and I have formulated the M tour autopogy
16:11
theory of aging and to teach people how important this is. So back to
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mtur M tour senses when nutrients are available, so M tours sending out signals,
16:22
bill grow, bill grow. Compared to our ancestral humans we eat all
16:29
the time, ancestral humans didn't get up in the morning and go to the
16:33
kitchen and open the refriger and start making breakfast. They didn't eat three meals
16:37
a day. For hundreds and hundreds of thousands of years, we evolved to
16:41
not be eating all the time, to go for substantial periods of time without
16:47
eating so that autopogy can be activated. But these days, again compared to
16:52
our ancestral humans, people eat breakfast, lunch, dinner, in between meals,
16:56
snacks, dessert, nighttime cocktails. Relatively speaking to our ancestors, we
17:03
eat all the time. So emtor is constantly being expressed, and autopogy is
17:08
not getting its adequate activity, and human kind health wise is suffering. And
17:15
so I like to draw attention to the health of humanity, which I think
17:21
is declining very rapidly. And I'm in my eighties now. Back when I
17:26
was a kid in nineteen fifties and nineteen sixties, we did not have health
17:32
epidemics. These days, we have an epidet of cancer, an epidemic of
17:37
diabetes, an epidemic of Alzheimer's disease, an epidemic of neurological diseases like Alzheimer's
17:45
Parkinson's disease, and so for that, we've got autism, we've got obesity,
17:48
we have an epidemic of epidemics these days. The health of mankind is
17:53
seriously deteriorated. And I think this imbalance between emtor and autopogy is a fund
18:00
of mental mechanism that's negatively affecting the health of most people alive today. This
18:07
is what rapamycin does for you. It goes into a cell, binds to
18:11
m to or partially inhibited, so activity of autoplogy starts to take place,
18:15
and you get this rebuilding and renewal and detoxification in every single cell in your
18:22
body. So I tell people that rapamycin is not a miracle fix. It's
18:27
not going to fix things overnight. But every single day, day after day
18:33
after day, every single cell in your body will start to work better.
18:37
But if you've got bone on bone arthritis, rap ofmcin is not going to
18:41
fix that. If you've got an embolism in your coronidarity that's about ready to
18:47
blow, and that's not going to fix these types of things. At the
18:52
cellular level, biologically and biochemically, everything will start to work better. So
18:59
it's not a quick fix of it's a long term commitment to healthy aging.
19:03
And I think you've said I know you've said a couple of things that are
19:07
really important. First of all, if anyone has any questions about where aging
19:11
begins, this is something also revolutionary that the discovery that all aging begins in
19:18
the cells, and so cellular metabolism and modulation of cellular activity, it's really
19:26
the key to your overall health. So that's number one. Baseline. Number
19:32
two is when you talk about autology and emptor and someone says, well,
19:37
how do I know if my autoplogy and m tour ratio is off? How
19:41
can you get a baseline to understand where you are before you would start any
19:47
program, so that you know what you're trying to do to where you are
19:52
today and where you want to get to. Very good point, Michelle,
19:56
we do not have good markers yet. Lab tests for mTOR and utoplogy are
20:02
being developed, but they're nowhere near ready for prime time yet, so it's
20:07
not really something that you can get a baseline marker. But I do encourage
20:11
people to take a baseline lab panel before they get started on rapimisin because you
20:18
want to track things like your iron and your hemoglobin, and your triglycerize and
20:23
some of these things. If you're taking too high a dose of rapamisin,
20:29
you can get things out of balance. Everything can cause some problems if it's
20:33
not used appropriately. But remember the difference between taking wrap of misin daily which
20:40
will cause immune suppression, and taking it just episodically once a week. That's
20:45
the big difference here. So most doctors are not aware of rappromisin. The
20:52
doctors that are aware of rapamisin, most of them only are familiar with it
20:57
in terms of it's used for organ transplant patients or chemotherapy. This is an
21:03
educational process to get your doctor educated about the health benefits of episodic rapamisin.
21:11
That's why I encourage people to read my book and give a Many people give
21:17
my book to the doctor, or they lend it to the doctor and take
21:21
the doctor so that they can start to understand their significant health metads to activating
21:26
autopogy on a regular basis. The unfortunate part of that is that many of
21:32
the doctors might take the book, but they might not really resonate to the
21:37
truth of the book because they're so ingrained. It's so ingrained in them to
21:41
be their allopathic approach. I don't mean to demean allopathic because it has its
21:48
place at some point, and particularly in crisis. However, you have to
21:53
find a doctor who would be open to looking at something that's completely new to
21:59
them, and so sometimes people go to the more comfort zone. So there
22:04
are other ways to get rapp of mice, and we can talk about that
22:07
in a few minutes, because Phil Mickens has been a guest on my podcast
22:11
and I A S which is the company that he founded and has the ability
22:18
to produce in India a very very bioavailable form of rappamcin Russia Wrappa pro very
22:27
good. Yeah, let's go back to the test though for a moment.
22:30
So you mentioned a few things that it does measure. The baseline test.
22:33
What's that test called, Well, it's just a basic lab panel. You
22:37
get a basic metabalic metabolic panel looking red blood cells and your white blood cells
22:42
and your liver enzymes and things, your triglycerides and so go ahead and explain
22:48
that test and what does it measure. The blood test that people want to
22:53
request to check the absorption of their rapp of mice, it's called sero Limas
23:00
is the name of the drug. Cyrill Limus is the generic name. So
23:03
when you go to lab Corp, which is the big international lab that does
23:07
blood draws, yes for the syrill limus blood test. And I like to
23:12
get my blood drawn around twenty to twenty four hours after I've taken my dose
23:17
the following day to check out the absorption is And I'm also recommending that people
23:22
occasionally take a blood test just before they take their next dose. So if
23:29
you take your dose today, seven days later, just before you take your
23:33
next dose, it's a good idea to get a blood test to see if
23:37
your seral limus test levels have gone down to zero, because you don't want
23:41
to keep them elevated all the time or you will get some immune system suppression.
23:47
So it's just the blood test that tracks this for you. Okay,
23:51
So that's what I needed to I wanted to clarify that the regular CBC test
23:56
is what you want to do just to get your overall ex work and then
24:03
when you're on rap of mice and you would take at least that one time
24:08
right afterwards and then a week later before your next dos so that you get
24:14
to see whether you're having the right effect. Have you ever had any awareness
24:21
of people who like taking it once a week have suppressed their immune system and
24:26
have to get off. The most common side effect of people taking rapp of
24:30
mice in once a week is a little painful mouth ulcer. They're called aptheus
24:36
ulcers. They go away in a day or two. I'd say based on
24:41
what I hear online and from some of the other experts, they say maybe
24:45
ten to fifteen percent of people may experience this and they keep taking it.
24:51
It goes away. Many times people have experienced it once don't have a reoccurrence
24:56
of it. But basically a lot of the people that are studying rapromise and
25:00
say that it is far safer than over the counter drugs, for example,
25:06
like ibuprofion or a unifin, which can cause serious side effects when they're not
25:11
used appropriately. Rappromise is very very safe when it's taken episodically. Okay,
25:17
And what's the dosage level that seems to be the magic milligram? The most
25:22
common dose is five to six milligrams once a week. But I want to
25:26
emphasize this is really a new area. We don't have enough clinical trials in
25:32
humans yet, and it's hard to get these clinical trials accepted because aging itself
25:40
is not an accepted disease by the FDA in the United States, and so
25:45
nobody's going to research a drug if they can't get an FD approved to treat
25:48
a disease. We have to get the FDA and the World Health Organization to
25:55
recognize aging as a disease and then funding come in to research it and it'll
26:02
accelerate the whole process. But as it is now, the rapamcin is approved
26:07
by the FDA, but it's really not approved as an anti aging drug.
26:15
Having finding a doctor to write a prescription for you, many people it can't
26:21
or won't. Then many doctors won't because they've got their specific standard of care
26:26
guidelines in the clinic they work in and so forth. But there are some
26:30
physicians who will do telemisit medicine visits for rap And then, as you mentioned,
26:37
International Anti Aging Systems has made rapa pro available from an overseas source and
26:41
I've tested in taking this rapa pro multiple times myself. Now it's a very
26:48
well formulated, very well absorbed product. The pharmaceutical company in India that is
26:55
making it as using a new nanotechnology. So the particle size is very very
27:00
small, it's well absorbed. I get really good, adequate blood levels when
27:03
I take my Wrappa Pro wrap of mycin product. So and that's another avenue
27:08
open to people to go on the International Anti Aging website and order it online.
27:15
One thing I like to educate people about if they do this and by
27:19
the Wrappa Pro product, they are not able to accept credit cards. Yes,
27:25
Haymond is either buy a bank transfer or an e check. Yes.
27:30
I did this the first time I found out my bank wants to charge me
27:33
forty five dollars for a wire transfer. I think exactly robbery. So just
27:37
select e check at the checkout and you put in your bank routing number and
27:42
your account number and it goes through flawlessly with no extra charge. Yes,
27:48
yes, that's a very good point. And I have ordered peptid bioregulators from
27:53
Ias and that's exactly how I did it, and it was seamless. First
28:00
you say, oh no, no credit cards, and then you know,
28:02
you get to the point where it's actually just as good to do it this
28:07
way with your bank. So I would highly recommend and film anyone who hasn't
28:11
seen my podcast with Phil Mickens. Please go on YouTube and just type in
28:19
ageless and Timeless Phil Mickens, M I C A N S and you'll learn
28:25
a lot about he doesn't He doesn't plug the company. So I'm plugging them,
28:30
but plugging them because we both have experience with their their products and their
28:36
service. So okay, So go back to autophogy for a moment. It's
28:42
becoming a buzzword right now because people are talking about intermittent fasting as an anti
28:48
aging mechanism, and of course there have been many, many studies on the
28:53
positive and the negative effective fasting. So I use personally the sixteen to eight
29:02
method that you I think use as well, and sometimes I'm not so good
29:07
at it. But you know, I try to finish my last meal by
29:10
my six or seven and then I don't eat again until the next day until
29:14
ten or eleven. I know, you go a little longer. I don't
29:17
know. For me. In the morning, I liked at least have a
29:19
smoothie or something that gets me, you know, going. I don't drink
29:22
coffee, so I don't have that caffeine stimulation, so I do need food.
29:29
But that seems to be the easiest way to fast. I had George
29:34
King on my podcast. He's a big fitness buff and out of Athens Grease,
29:41
and he trains his people to fast all during the day. And I
29:45
don't know. I could not work out, I could not do the mental
29:48
exercises of my business without having nutrition. So I think you have to decide
29:55
what works for you. This is not one size fits all kind of but
30:02
giving your body a rest even while you're sleeping sixteen hours is not that hard
30:07
to do. So I would recommend that for anyone who's starting out and wants
30:11
to try to stimulate autophogy, which is basically like your cellular housekeeper, you
30:18
know, it comes in and actually, doctor Gundry just did a whole thing
30:22
the other day because he's pushing his product called Biocomplete. Biocomplete three. You
30:27
probably have heard of that one with Okay, well, it's pre post pre
30:34
biotics, post biotics, you know, and he talks about all the different
30:40
ways that you can get to autopogy. But you know that everybody you know
30:45
has their own way of doing it. But I think this one is the
30:48
easiest. So I'm just recommending that to anyone that wants to start out trying
30:53
intermitt and fast and without having to do it during the daytime hours, and
31:00
to emphasize what you're sharing with your viewers, you're intermittent fasting is the natural
31:07
way to get a better balance between mTOR and autopogy. WRAPAMCIN does it for
31:12
you when it crosses the cellular membranes and binds to mTOR, But the natural
31:18
way to do this is intermittent fasting, and the sixteen eight protocol that you
31:21
mentioned is probably the most familiar and probably the most commonly used one. And
31:27
I do that most of the time. I'm not fanatical about it. If
31:32
we have a social event or something, I'm not going to tell people I'm
31:34
not going to participate become them fasting. You know, life is to be
31:38
enjoyed. But the other thing that I do periodically is I occasionally do a
31:45
two or three day fast. Some people can't do that, but for me
31:51
it's easy. I just I realize that a lot of my heat eating is
31:55
habit. I set in my mind to not do it. I go for
31:59
I've gone both two and three days multiple times, and I just drink herbal
32:02
tea water or black coffee, organic coffee with no cream. Or sugar or
32:07
anything, and those are my liquids, and I it's not a problem for
32:13
me. And when you go for longer periods beyond a sixteen hour fast,
32:17
you get much much more autophagy activity. So you're accelerating every building your product
32:24
and body by going for longer periods of fasting. Occasionally, it's nothing you
32:30
want to do every week, but occasionally I think there's tremendous benefits to it.
32:35
That's very good to know. And I think you can also drink bone
32:38
bras if you need something warm, like I always drink herbal tea all day
32:43
long anyway, but I always, you know, I am eating, but
32:46
I you know, just like you, we're very disciplined about our choices of
32:51
guy and nutrition. So but yet you're still putting your cell your activity to
32:58
work, and you're not inspiring or initiating autophogy. So but I think if
33:04
you, if you wanted to try the longer fast, that's what you just
33:07
suggested, you could add just you know, the bone broth with maybe some
33:13
vegetables that have been marinating in it that will give you some degree of nutrition
33:19
if you need that. Is that is that okay with you? To again
33:22
individual protocols. Some some people are going to be different. Some people will
33:27
need a little nutrients to get by because some people will go into a blood
33:34
sugar crash and it's not fun to be in hypoglocemia, and so you need
33:39
to prevent that, right, Yeah, and some people the blood, your
33:43
blood sugar is more sensitive, so you do need that. You know,
33:46
if you get a spike, I mean, if you get a depression and
33:51
you feel if fatigued, that's not a good thing. You're it's kind of
33:54
react, kind of productive. Right, So when is a good time to
33:59
start wrapping mice and if you were going to use it right now? Okay,
34:05
but for all else, So let's talk a little bit first about who
34:08
should take it and who shouldn't take it. That was going to be my
34:12
next question, so good, go ahead. First of all, wrap a
34:15
micition should never be taken by children. Yeah, childhood is a time of
34:20
rapid growth, so you don't want to interfere with m to or during a
34:23
period of rapid growth. Pregnant women should never take it because a growing fetus
34:29
is the fastest growing situation we know of, and you want to inhibit the
34:34
growth of the fetus. During pregnancy, so pregnant women should never take it.
34:38
We don't know what's the best age to start taking rapamycin. It's probably
34:44
a very individual thing. For example, somebody that's healthy at fifty could take
34:50
it. Somebody that's unhealthy at forty maybe get started ten years earlier taking it.
34:55
That has not been determined. And we also don't know, so what's
35:00
the optimum dose or what's the optimum frequency of dosing. Is it five milligrams
35:06
once a week, is it five milligrams every other week, or maybe ten
35:12
milligrams other other We just don't know the answer to these questions. But from
35:15
the jone Manic study, we know that five or six milligrams once a week
35:21
is not only very safe, it gives some significant health benefits that were measurable
35:27
in terms of enhancement of the immune system. But if we go back to
35:31
look at the animal models, virtually every single disease that we know of responds
35:38
favorably to rapamycin. So there's good animal research that suggestive that almost all human
35:50
conditions will respond to rapamycin. And I want to emphasize that I'm so passionate
35:57
about wrap of micin, but it's not the only thing for people to consider
36:00
for healthy longevity. I'm also passionate about the human gut microbiome and teaching people
36:06
about the importance of post biotic metabolites. It's not commercial probiotics that help to
36:12
regulate your gut probiotic bacteria. It's the postatic metabolites, and that can only
36:16
happen with a healthy plant based diet. And most people aren't consuming attic amounts
36:22
of dietary fibers and polygonols. And then there's glutathion to think of, and
36:28
coenzyme Q ten and an exercise exercise exercise to study. On my website,
36:36
a group of Battalians studied some elderly people from age ninety four to one hundred
36:40
and five, and their goal was to find out what's the most important thing
36:45
for healthy aging. One thing for healthy aging maintain your muscle mass correctly.
36:52
So you've got to do some form of strength building exercise regularly or you will
36:58
gradually lose your muscle mass. And I emphasize the people at things like bicycling
37:05
and swimming and jogging. Those are great aerobic exercises, but you are not
37:09
building muscle mass. How to get into the gym and do some form of
37:14
strength training in order to maintain your muscle mass. Very important. Well,
37:19
as long as you've gone off onto that avenue, let's talk a little bit
37:22
about the microbion. I was going to call that to our next meeting,
37:28
our next podcast, where we would have you come back. But I think
37:30
it's so important and it's so integral to anyone that's considering rapamcin or understanding of
37:37
the overall impact of longevity and what contributes to that healthy living. By the
37:45
way, Dan Buttner is going to be at the American Academy of Anti Aging.
37:49
He's the one of the keynote speakers along with doctor Oz. And you
37:53
know, Dan Buttner wrote the books on the Blue Zones, and so I'm
38:00
sure that I haven't read his book, but I am sure that it must
38:04
discuss the microbion of the people in these blue zones that they eat such a
38:08
healthy diet and a lot of vitamin D. Yeah, I was just gonna
38:14
say, they get out in the sun or they take you know, an
38:16
extra supplement the winner. If it's a climate that it's interesting. Most of
38:21
the climates of these blue zones are very temperate, tropical Costa Rica. Even
38:29
Loma Linda in San Diego is kind of temperate, you know, compared to
38:34
the northern part where I am of California. And then of course there's Sardinia,
38:39
and there's one of the other blue zones. I think there's one in
38:45
South America maybe, But anyway, but the other thing that they say that
38:47
we haven't touched on, other than what we'll get you in a moment with
38:51
Buddhascion and Microbion is the attitude of the people. So, yes, they
38:58
don't have a lot of these places mote, they don't have physical fitness facilities,
39:02
but they walk up hills, so they're building the muscles of their gluts
39:09
and their legs and everything by doing some pretty exhaustive walking. And but their
39:15
attitude of healthy aging, of you know, being socially connected, having some
39:21
purpose in life, those are all things that we haven't really touched on Ross,
39:25
but I think they're important to add to our recipe here of healthy aging.
39:31
So but let's just put that aside for a moment. You can touch
39:36
on that in a moment. Let's go through the microbiome. I really think
39:39
one of the most important books. Oh thank you for showing that for your
39:44
viewers. This is a free booklet that you can have access to by going
39:49
to my website Natural Pharmacists dot net forward slash oh heira book that's oh h
39:54
h I r a b oh okay. And this book talks about out the
40:00
mechanism of the microbiome. You've got probiotic bacteria, but we learn that the
40:07
job of your probiotic bacteria is to break down dietary fibers and polyphenols into smaller
40:15
molecules that have a tremendously wide range of biological activity. We call these compound
40:21
post biotic metabolites. And it turns out that it's the post biotic metabolites that
40:25
are master regulators of our health, not just for the microbiome ecosystem, but
40:31
they absorb this systemically in your circulation, the influence and regulate every single organ
40:37
system, including the brain and the immune system. So it's not so much
40:40
the bacteria, but at the compounds the bacteria create that are master health regulating
40:46
compounds in our bodies. And most people have a total misunderstanding of commercial probiotics.
40:53
Commercial probiotics is not going to give you a healthy marcibiome. It may
40:58
help. There are some studs that show benefit, but basically I've got multiple
41:02
studies that show that from ninety to ninety five percent of children and adults,
41:08
and this is in the United States, but it's also true of other developed
41:12
countries do not consume adequate amounts of dietary fibers and polyphonols, and those are
41:17
the foods for your probiotic bacteria. So almost nobody's giving themselves adequate food to
41:23
create a healthy microbiome so they can produce the post biotic metabolize, and consequently
41:29
everybody's got health problems, or at least for the most So, yeah,
41:32
it really comes down to diversity, diversity, diversity. I try to get
41:39
people to understand the importance of consuming a little bit of as many different types
41:45
of colored fruits and vegetables every day as you can. You can get access
41:50
to an eight minute YouTube that I created for people. Just do a Google
41:53
search for YouTube Ross Salad buzz b used the zebra and to make a micromam
42:01
supportive salad and save a lot of time doing so. Yeah, I think
42:06
that my assistant Alexis will put all of this into the show notes or we
42:10
have an actual icon on our website. For Michelle recommends, and we normally
42:17
our guests like to do exactly what you're doing, which is to encourage people
42:22
to order some of these follow on or to go to links like you're du
42:28
providing, so we will make sure that everybody sees. And I did watch
42:32
your YouTube video. That's a lot of fun and it's not that difficult to
42:37
make that salad, for sure. You just have to be sure to like
42:40
I go to the Farmer's market or even you can go to Whole Foods or
42:45
Trader Joe's or where we just make sure you get organic and I always try
42:49
to buy the freshness that I can. And then hey, you can make
42:52
that salad and eat it without dressing, you know, just put the salad
42:55
in the fridge in an air tight container and you have your meal. You
43:00
don't even have to start prepping every thing. So it's it's definitely a fun
43:06
adventure to get watch that video of Ross's salad buzz. Okay, So go
43:12
back to gluteacion. Okay, it's probably one of the most misunderstood antioxidants.
43:16
It's the master antioxidant of the body, but it's also one of the hardest
43:22
to absorb, and so you know people have taken blutacion pills that they're not
43:27
doing anything. You can go get an IV but that's a real time and
43:30
expense commitment. But of course it does have you know, and it only
43:35
lasts a couple of days. So what is the magic formula for building Oh
43:43
oh, of course NAC. I forgot about mentioning a precursor of an acetyl
43:46
system helps to encourage the development of bluetacion. But hey, you know what,
43:52
ross I did the DNA Company's test recently with Kashif Khan and he was
43:59
a guest on our podcast. So you know, my glutathione gene is not
44:05
very powerful. It's not working to help me to develop the initiate gluteacion even
44:12
with the help that I give it with the NAC. And I've taken even
44:17
ivs a few times, but that's just two time consuming. So what is
44:22
your magic bullet for people who want to build their glutacion reserves and not have
44:31
a disappear in two or three days so that you have to be replenishing well.
44:37
A very unique strain of probiotic bacteria called Lactobacillus fermentum me three. We
44:43
call it YEAH for short, ye that particular strain of bacteria synthesizes glutathion.
44:50
Yes, synthesize a lot of it. We've got human clinical trials to show
44:53
how effective it is. This was discovered it was actually extracted from the intestinal
44:59
track of a healthy one year old child back in nineteen ninety five. Originally
45:05
tested it and found out that it's antioxidant activity it was off the charts,
45:08
so it took a couple of years to figure out why. And it not
45:14
only synthesizes glutathione, it synthesizes manganese superoxide dispute taste, which is another really
45:19
important intracellular antioxidant enzyme. So this has got powerful, powerful antioxidant activity,
45:25
and when you take a capsule of it orally, it's acid stable. It
45:30
does not get destroyed in the stomach acid. When you're small intestine, those
45:36
bacterias start to produce glutathione twenty four hours a day, sosting your glutathione levels
45:43
when the bacteria are making it, and people taking this for four weeks get
45:47
a twenty six percent boost in total antioxidant activity, which means the extra glutathione
45:53
is recycling and reactivating oxidized vitamin C and oxidized vitamin E. So your antioxidant
46:00
protection is coming up. And this product was discovered at the University of Tartu
46:07
in Estonia that's over an Eastern Europe bordering on question. So it is licensed
46:15
to a company in France and it's available in the United States under the brand
46:21
name Regiactive. That's rag apostrophe activ that's an acronym for active regeneration. The
46:30
Regiactive products contain lack of bacillas fermentum ME E three. There's several different products.
46:37
There's immune and vitality, cardio wellness, detox and liver health. Then
46:43
those three formulas have some supplemental ingredients in them to support either your livery or
46:49
immune system or detoxification and cardio wellness. And then the fourth product is just
46:53
Essential ME three and that just contains the ME three bactery with no other gredients
47:00
and those are available online. But it's the most efficient and cost effective way
47:07
to boost your glue of iron levels on a regular basis. So if you
47:12
take that, let's just say you took the Essential one, all the other
47:17
targeted ones, the livergy, tax, the cardio there if you're taking the
47:22
Essential. You're going to get the benefits of all those other areas, you
47:24
just may not get these other ingredients. But is the Essential one a stronger
47:30
dosage of the glut of the three? It's it's not a stronger dosage.
47:37
It just doesn't contain all the other supportive ingredients. Right. The dose of
47:43
the three products that have supplemental ingredients as two capsules daily, the three,
47:49
just as the factory is one a day. I got it, okay?
47:52
And how much does that cost? To tell prices about? I think it's
47:57
like forty nine ninety five for a box of six you take two capsules daily,
48:00
so some one month supply for about forty nine ninety five. But if
48:04
you buy the essentials, is it still the same price with one of days?
48:07
So are you getting that's a little bit less? I don't have that
48:10
price in mind, but it's like, okay, that's great, Okay,
48:16
but you get still only get one month supply for the Essential it's one to
48:23
day, but a box of thirty or sixty, I don't have to check
48:28
that. Okay, that's okay. I'm going to have a Lexis look at
48:30
for that online and we'll put that in our I'll send a slide to you
48:36
that has them all pictured also that you can post for people to see.
48:39
Okay, and just putting Ross Pelton in that. Is there any kind of
48:45
out of my website. I've got articles on all these things, right,
48:49
well, I was asking by using your name, is there any kind of
48:52
a discount or is it just I don't make any profit on this, I
48:55
get no commissions on it. No, Okay, just just curious. But
49:00
because a lot of times we have some kind of a cold, right But
49:05
that's fine. Yeah, I mean it seems to me that this is like
49:08
a breakthrough for everyone, because I can't tell you the amount of money I've
49:16
thrown away by probiotics that never make it to the colon, and so I
49:22
think this is a case for most people it's just your stomach acid breaks down.
49:27
Even the terra coated ones are not nearly I mean, they're much better,
49:30
but they're not still not doing what these met three does by being developed
49:37
in the way that you've described and and and it's and it's metamorphosis. Right,
49:45
So why I have two questions for you. Why did why did they
49:47
go to Easter Island in the beginning for the rap of license and why did
49:52
they go to this Estonia for the M three? Why those two places?
49:59
First, these island for centuries, horses ran wild on Easter Island. There
50:06
were more horses than people. And where horses are common, there's usually tetanus
50:13
in the soil. So the scientists in Canada were curious why all the Easter
50:20
Islanders who went barefoot all the time never got tetanus. So that's why they
50:25
went to Easter Island to see if there were they could find some answer to
50:30
that question, and they found wrap of misin, which is an antifungal drug.
50:35
Actually it's a natural antifungal agent, but also an anti biot natural antibiotic.
50:39
So that's why they chose Easter Island for that scientific expedition, and ultimately
50:45
they discovered rapamcin. And the other question why the University of Tartu in Estonia.
50:52
At the University of Tartu, they have one of the most advanced microbiology
50:57
labs in the world. Back in their early sixties and seventies, the microbiology
51:02
department at the University of Tartu was studying the microbiome of the Russian cosmonauts to
51:08
see if there's any changes in their microbiome with spaceflight, so they've got decades
51:14
in decades long history of working with the microbiome. They conducted a study in
51:22
conjunction with Sweden to see why Swedish people had such a high incidence of skin
51:30
problems like accent, acne, and ezema, and Sian kids had almost zero
51:37
had these two groups of people from Sweden, children from Sweden and Estonia took
51:40
school samples and looked at their microbiome, and that's how this one sample of
51:46
lack of basillis fromentum AEMY three got extracted. And then a couple of years
51:52
later the scientists were studying a wide range of lack of basillis bacteria to see
51:57
if any of them possessed antioxidant activity. Most of them failed, but when
52:01
they tested ME three, it's antioxid and activity was just off the charts,
52:07
and so it took them a couple of years to figure out why this ME
52:12
three has such powerful antioxid in activity. It's because it synthesizes glued to thione
52:16
and also manganese superoxide dismutase. I want to say one more thing about how
52:22
important glued to thione is. It's so critical for the immune system our white
52:28
blood cells, lymphocytes and natural killer cells and T cells and B cells circulate
52:32
around in our system. It's our frontline of our immune system, always on
52:37
the alert looking for bacterial and viral invaders and so forth, and glued to
52:42
thione is absolutely critical for the activity of your white blood cells. And in
52:46
one study, scienceists said even a slight decline in gluet to thione levels is
52:52
a major decline in the activity of your immune system. You know, that's
52:57
really important for people to recognize how important it is to keep gluetothione levels up.
53:02
And glutathione is really now a biomarker of aging because the scientists that discovered
53:10
chromosomes, the telomeres and telemerase and how they regulate aging, they now understand
53:19
that glutathione levels parallel telomeres and telemerase, and we know that telomeres and telemerase
53:24
are what protect our chromosomes in our DNA. So that's a biomarker of aging,
53:30
your telomeres telemerase, but glueothione parallels, So it's the antioxidant activity of
53:36
glueothione which will actually slow down the shortening of your telomeres and accelerate the production
53:42
of the telemerase enzyme, which is all related to life extension and antiaging.
53:46
I agree. Well, the other thing, the Clicksilver Scientific makes a lipisomal
53:53
glutacion that you can put under you, and then my doctor in Beverly Hills
54:00
the injectible the subque. Do you think those two are doing anything better than
54:06
or as good as the MET three or should you do all of that together?
54:09
Well, I think that ME three is the best, and I'll tell
54:14
you why. Intervenous glue to thione very effective, but you have to make
54:20
a doctor's appointment, drive to a doctor's office, sit there and get the
54:23
IV. It's pretty expensive and it gets IV Gluteathione gets oxidized very quickly.
54:29
So if you get an IV glue to thion today, three days later it's
54:32
gone. So you need to do IV glutathione a couple of times a week,
54:36
and again time consuming and expensive. Yeah, the better absorbed glutathione products,
54:44
the liposomal formulations that do get through the stomach, they do get better
54:50
absorbed because glutathione orally is not absorbed, but if they put it in a
54:53
liposomal delivery form, it will get better absorbed, but nothing has ever come
54:59
close toge getting plasma levels of glue tooth ione the way the E three has.
55:04
In human classical files, people got a forty nine percent increase in the
55:08
ratio between reduced glue th ione to oxidize, which is active to inactive.
55:14
The product in the world has ever come close to getting this level of increased
55:19
glue tooth ione. So nothing has come close to the product. You could
55:24
do all three, like you know, take the under top can, but
55:30
I don't unless somebody has severe health problems, I don't think there's much benefit
55:34
in doing all three. I would just stay on the regiactive products regularly.
55:38
That's that's great. I hope everybody's listening. It'll save you a lot of
55:43
money too, because the sub Q injections are the ivs are like three or
55:49
four hundred dollars, so you got to you know, factor that cost,
55:52
the cost factor in. Well, we're also we've run out of time.
55:55
I'm so sorry. I knew this would happen because we have so much cover.
56:00
But as we discuss, we'll have you come back next year and we'll
56:05
do a follow up with the other side of we've touched on the microbio,
56:09
but we've got lots more, and you'll have a lot more by then too,
56:12
because you keep writing these books and get making discovery. So I just
56:16
want to thank you so much for taking time today and being so helpful and
56:21
so knowledgeable. And this is something that is your passion and you show that
56:25
in every in every ounce of your DNA is about helping others, and I
56:31
think that's so admirable. So thank you again, and I hope you have
56:37
a beautiful day, and goodbye to everyone that's listening and watching today. And
56:40
I hope this podcast helped you and that you'll listen to it when we're going
56:45
to be live in about a week on YouTube and on my website, and
56:50
we will have the Michelle Recommends with all of Ross's links and referrals for products,
56:57
So everybody have a great day. Thank you so much,