1050-Biomolecular Condensates for Protein Degradation
This research introduces a novel therapeutic platform using nanoscale biomolecular condensates to achieve highly selective intracellular protein degradation. By combining antibody-guided recognition with a proteasome-targeting motif, these synthetic droplets successfully penetrate cells and recruit endogenous machinery to clear disease-causing proteins. A critical breakthrough of this design is its ability to distinguish between nearly identical proteins, specifically degrading the oncogenic KRAS G12V mutation while leaving healthy wild-type KRAS untouched. The condensates are stabilized by a…
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