406-Targeting and Tracking mRNA Lipid Nanoparticles
This research into lipid nanoparticles (LNPs) highlights their critical role in delivering RNA therapeutics by protecting genetic cargo and facilitating cellular entry. These delivery systems are complex structures typically assembled through microfluidic mixing, resulting in an ionizable lipid core that responds to physiological pH. Researchers utilize diverse imaging modalities, such as optical microscopy and nuclear imaging, to track how these particles move through the body and enter specific cells. Advanced strategies to refine targeting and expression include modifying the RNA itself…
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