787-Radiotherapy Synergizes with Inducible AAV
This research demonstrates that radiotherapy significantly improves the effectiveness of adeno-associated virus (AAV) gene therapy by triggering epigenetic changes that boost transgene expression. Scientists developed a specialized AAV platform using an interferon-inducible promoter to ensure that therapeutic cytokines, specifically IL-12, are only produced within the irradiated tumor site. This localized approach prevents the systemic toxicity typically associated with cytokine treatments while effectively transforming "cold" tumors into "hot," immune-active environments. The combination of…
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