185-OTX2 Regulation of Splicing in Medulloblastoma
This article investigates the molecular mechanisms driving Group 3 medulloblastoma (MB), an aggressive pediatric brain tumor. It establishes a noncanonical role for the transcription factor OTX2 in regulating alternative splicing, which is crucial for maintaining the tumor's stem cell state. Specifically, the study demonstrates that OTX2 interacts with the large assembly of splicing regulators (LASR) complex to control a pro-tumorigenic splicing program, partially independent of its DNA-binding function. Targeting one of the key OTX2-regulated differentially spliced genes, PPHLN1, through…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.