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POEMS Syndrome: Clinical Update and Management
POEMS syndrome is a life-threatening, multi-system disorder driven by an underlying plasma cell neoplasm, characterized by mandatory major criteria such as polyneuropathy and a clonal plasma cell disorder. Diagnosis requires a careful combination of clinical evaluations, radiographic bone assessments, bone marrow biopsies, and elevated vascular endothelial growth factor (VEGF) levels. Because the condition's pathogenesis remains poorly understood, risk stratification relies primarily on the patient's clinical phenotype and specific prognostic indicators like age and renal function. Treatment…
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