Latest / Biohacking Autism with Nadia Elkhatib. / What’s Driving Inflammation in Autism? | Essentials with Dr. Horowitz
Transcript
- 0:35Welcome back to Biohacking Autism,
- 0:37the show about real solutions for people with autism and the ones who love them.
- 0:41I'm Nadia Elkhatib, and here is the question I've been thinking about going into
- 0:46this conversation. Alzheimer's is neurodegenerative disease.
- 0:50Autism is a neurodevelopmental condition.
- 0:53One shows up at the end of life and one at the beginning.
- 0:57So, why does the biology underneath them look so similar?
- 1:02Does it or does it not? Let's
- 1:05Take a look at that. So I've felt for a long time that there's a connection there.
- 1:09And I think the reason we don't see it is just the label.
- 1:12The moment we say the word autism,
- 1:15we stop looking at the body. But if you take that label off and look at the biology,
- 1:20what do you find? You find inflammation,
- 1:22immune dysregulation, mitochondria that's not keeping up a gut that isn't holding
- 1:27its barrier, you find the same thing in.
- 1:30Chronic illness
- 1:31Just before we start this conversation,
- 1:33my disclaimer: this conversation is educational.
- 1:36We're going to talk about mechanisms.
- 1:38evidence and tests and treatments Richard actually uses because that's what this
- 1:45show is for. Now nothing here is medical advice for you or your child
- 1:49and nothing replaces your own clinical team.
- 1:52Richard, welcome to Biohacking Autism.
- 1:55Thank you, Nadia. Great to be with you today.
- 1:57I've seen over 13,000 chronically ill patients during the last 42 years
- 2:01~ looking for answers. And what I discovered is there was this 16-point model
- 2:06I call it MSIDS. MSIDS stands for multiple systemic infectious disease syndrome.
- 2:10And in this model, which we'll discuss today in detail regarding autism,
- 2:14~ I found that there are infections,
- 2:16environmental toxins, microbiome issues.
- 2:19Intestinal hyperpermeability with leaky gut,
- 2:22which affects your blood-brain barrier,
- 2:24with or without mast cell activation,
- 2:25vitamin mineral deficiencies, and sleep disorders.
- 2:28And I call these the six rivers of inflammation that have 10 downstream effects:
- 2:33inflammation inflammation, mitochondrial dysfunction,
- 2:35hormonal dysregulation, immune issues,
- 2:38autoimmunity, POTS dysautonomia,
- 2:41where your autonomic nervous system is dysregulated.
- 2:43They people have liver problems,
- 2:45neuro and psychiatric issues.
- 2:48Pain syndromes and finally deconditioning.
- 2:50So these are the 16 points. And it's it's like going into a doctor with
- 2:5416 nails in your foot, complaining of foot pain,
- 2:56and the doctor finds two nails,
- 2:57pulls them out, and says, Come back in a month and tell me how you're feeling.
- 3:00It's all the same thing. It's inflammation.
- 3:02So you're right. I 100% agree with you.
- 3:04Stop naming the disease and trying to throw drugs at it.
- 3:08Every chronic illness has chronic inflammation underlying it.
- 3:12You've got to figure out where these 16 factors are.
- 3:15driving inflammation are coming from,
- 3:16and that's the really, I believe,
- 3:18important conversation we have to have today.
- 3:20we're all, yes, chasing these labels.
- 3:22So, you've described three threads that run through ADHD,
- 3:29autism, and Alzheimer's.
- 3:30microglial activation, cytokine dysregulation,
- 3:34and blood-brain barrier disruption,
- 3:37but also a genetic piece which is the mTOR pathway.
- 3:41So in plain-ish language, can you tell me what each of those specific points are,
- 3:47what they're doing in the brain,
- 3:49and also what's mTOR and autophagy,
- 3:52and why a pathway that's dysregulated in Alzheimer's also shows up in autism
- 3:56and why and where it's linked to brain overgrowth and hyperconnectivity.
- 4:04there are these small cells in the brain called microglial cells.
- 4:07And you get microglial activation with inflammatory cytokines and chemokines,
- 4:13these very inflammatory molecules come out.
- 4:15~ and without getting too technical,
- 4:17there are these switches that turn on inside the nucleus of your cells.
- 4:20One of them is called NF kappa B.
- 4:22And when this particular switch gets turned on,
- 4:25you get these very inflammatory molecules.
- 4:28It's like pouring gasoline on a fire with TNF alpha,
- 4:31interleukin 1 beta, IL6, IL8, IL10.
- 4:34All these inflammatory molecules come out from these very small cells
- 4:38in the brain called microglial cells.
- 4:39~ what causes the microglial activation?
- 4:42Well, infections can cause it.
- 4:45Bacterial infections like Lyme and Bartonella,
- 4:47viral infections like herpes infections,
- 4:50parasitic infections like toxoplasmosis or babesiosis or fungal infections.
- 4:55All the four different types of infections and multiple environmental toxins will
- 5:00all cause microglial activation.
- 5:02And in one of these pathways called mTOR,
- 5:05the mechanistic target of rapamycin,
- 5:07what they found out genetically is that both in autism and in Alzheimer's,
- 5:11the mTOR pathway was being overstimulated.
- 5:13Now
- 5:14You need a balanced mTOR pathway because mTOR is needed for your cell metabolism
- 5:18to work well. You need it for protein synthesis,
- 5:21for metabolism, but also for getting rid of let's call it taking the garbage out.
- 5:26So, what is autophagy? Autophagy is when your mitochondria,
- 5:30the powerhouses of your cells,
- 5:32they have nothing protecting them from all the free radical oxidative stress that
- 5:36happens from infections and toxins and microbiome issues
- 5:40and vitamin mineral deficiencies,
- 5:41all the things driving inflammation.
- 5:43affect the mitochondria of our cells.
- 5:45And if you don't have healthy mitochondria,
- 5:47right, in aut in autism and both in Alzheimer's,
- 5:49they know you need healthy mitochondria or the brain cells just
- 5:53do not work correctly, right? In fact,
- 5:55every organ of your body needs it.
- 5:56Well, in the mTOR pathway, they found out one of the genetic links between autism
- 6:01and Alzheimer's is an overstimulated mTOR.
- 6:03So in autism, you see large brains called macrocephaly.
- 6:07Right, with too much connectivity in some areas of the brain,
- 6:10not enough connectivity in other areas of the brain.
- 6:13And in Alzheimer's, what it does is it causes elevated levels
- 6:16of these Alzheimer's biomarkers,
- 6:19like phosphorylated tau, p-tau 181,
- 6:21P tau 217, ~ lower beta amyloid 4240 ratios,
- 6:26neurofilament light, glial fibrillary acidic proteins.
- 6:29These are all markers, indirect markers of inflammation in the brain.
- 6:33And what's fascinating, and I by the way,
- 6:35at the recent MAPS conference in Philadelphia I was the only speaker
- 6:39to mention that these same Alzheimer's biomarkers are showing up in the children,
- 6:43like serum neurofilament light and glial fibrillary acidic and tau and p tau.
- 6:49It's showing up in the children just like it shows up in
- 6:52the adults with Alzheimer's, which means we have a way of screening these kids
- 6:56theoretically before this ever happens.
- 6:59Now, this is
- 7:00Absolutely.
- 7:00understand? I know, it's mind blowing,
- 7:02right? So I know.
- 7:02I've never heard it before. I have
- 7:04never heard that before, which means I've never even thought about testing
- 7:08it before, This is so new. And I hope everybody listening is as mind-blown as me.
- 7:15Yes, this is great. These are new biomarkers that we've never looked at for autism.
- 7:20and we know in the mother, we know that if if a mom,
- 7:22for example, has inflammation,
- 7:24if she has maternal inflammation,
- 7:26the risk of autism spectrum disorder is 2.75 almost three times higher.
- 7:30But it doesn't matter where the inflammation is coming from in the mother,
- 7:33whether it's a viral infection,
- 7:34a bacterial infection, a chorioamnitis,
- 7:37she gets infection of the uterus and the air.
- 7:39It doesn't matter where it's coming from,
- 7:41the odds are going to be higher because inflammation in the mother obviously drives
- 7:46inflammation in the children. They're directly linked up.
- 7:49So now we have a way. Think about this.
- 7:51You're a mother, you want to have children.
- 7:52You can measure your inflammatory biomarkers,
- 7:56CRP, C reactive protein, indirect marker of interleukin 6.
- 8:00Why is that important? Well, in autism and in Alzheimer's,
- 8:04they find elevated interleukin 6 levels in the brains of autism
- 8:08and an Alzheimer's disease. Why?
- 8:10Because that switch inside the nucleus,
- 8:12NF kappa B, gets turned on. That's one of those inflammatory molecules gets pushed
- 8:16out. So
- 8:17A mom can check for environmental toxins,
- 8:20for infections, for microbiome issues.
- 8:23The mother theoretically could check all 16 MSIDS factors related to inflammation.
- 8:28they do not screen the women for Lyme and associated coinfections.
- 8:31It's just not standard. They they'll check them for syphilis,
- 8:34right? They'll check them for hepatitis,
- 8:35they'll check, MMR, they'll check a lot of things,
- 8:37but they don't check. Now, just to give you a perspective,
- 8:40for Lyme disease right now, BMG Global Health just four years
- 8:43ago published that 14.5% of the global population
- 8:47One in seven people on the planet has now been exposed to Lyme disease,
- 8:50right? That's a lot of people.
- 8:52So we know that Lyme can be transmitted to the fetus.
- 8:55Bartonella can be transmitted to the fetus.
- 8:58just to add a little something there,
- 9:00this is what I advocate for. Don't wait for some for a practitioner,
- 9:06a doctor, somebody in a white coat to tell you,
- 9:09let's test these things. Take this information and take it to your practitioner
- 9:14and say, I've done the test, the online test.
- 9:17I'm worried about Lyme. I'm planning on getting pregnant,
- 9:21or I am the mom of a child with autism.
- 9:24Let's test these things in me and my child.
- 9:27You
- 9:27can do that. You can take charge of your health.
- 9:29We cannot wait until the medical system catches up because the solutions are there,
- 9:35the tests are there,
- 9:36We do medicine thinking it's one cause,
- 9:38one disease. That's an outdated model.
- 9:40The model that now needs to be adopted for chronic illness,
- 9:43no matter what you're calling it,
- 9:44as we talked about, it has to be a multifactorial model of where the root causes
- 9:49of inflammation are coming from,
- 9:50So if people hear brain inflammation in autism,
- 9:54~ they picture a swollen brain.
- 9:56in your language. What is neuroinflammation and how would a parent ever know
- 10:01increase in serum neurofilament light in a child raises the risk of autism by 19%,
- 10:07which means you can do a blood test.
- 10:10And you can look at things like serum neurofilament light.
- 10:14You can look at glial fibrillary acidic protein.
- 10:16You look at Tau, not just CRP,
- 10:19indirect market of interleukin 6,
- 10:20or sed rates or VEGF. In fact,
- 10:23in my section in the book where I discuss these inflammatory pathways,
- 10:27I discuss 10 different inflammatory markers as a first line that you can do.
- 10:31The second level, you can look at free radical oxidative stress in the body.
- 10:36By looking at, for example, lipid peroxides,
- 10:38how much free radical oxidative stress is damaging your membranes.
- 10:42When we were talking about the mTOR pathway,
- 10:44right, what they found in this is if the mTOR is overstimulated,
- 10:48you don't get autophagy. You can't get rid of these damaged mitochondria.
- 10:52These damaged mitochondria just keep causing inflammation in the brain.
- 10:55You've got to take out the garbage,
- 10:57get rid of these damaged mitochondria.
- 10:59And in the studies they did, whether it was suramin,
- 11:01this drug for African sleeping sickness,
- 11:03or
- 11:04Broccoli seed extract, sulforaphane glucosinolate,
- 11:06which affects another inflammatory pathway called NRF2.
- 11:10They found both in Alzheimer's and in autism,
- 11:13the brains woke up. Like the kids' behavior was better,
- 11:16their cognition was better. They found a salmon Alzheimer's because what you're
- 11:20doing is you're finding ways of manipulating these inflammatory pathways.
- 11:24The NRF2 pathways lowers inflammation and increases autophagy.
- 11:28let's talk about the framework,
- 11:30right? So I'd love to go through all 16 factors,
- 11:35each one of them.
- 11:36Because I think this is the most useful thing right now for a parent that they
- 11:40can take from this conversation.
- 11:42But let's first talk about the shape of the framework.
- 11:45So it's the 16 MSIDS factors,
- 11:48the first six you call the rivers of inflammation:
- 11:51infections, environmental toxins,
- 11:54the microbiome, leaky gut and mast cells,
- 11:57nutrient deficiencies, and sleep.
- 12:00And then there's 10 downstream effects,
- 12:02mitochondria, immune dysregulation,
- 12:04autoimmunity, hormones, liver and neurological,
- 12:07autonomic psychological pain,
- 12:10and deconditioning. So why rivers can you can you describe this image that
- 12:15you have in your head?
- 12:16the toxins, the microbiome, they play a huge factor when you look at autism.
- 12:21I mean, that's what the literature is showing.
- 12:23If you speak, to example, for naturopaths or doctors that are treating,
- 12:27they're telling me, and again,
- 12:29this is not yet published because the literature online,
- 12:31for example, it's a little bit all over the place.
- 12:34Some studies show from the IDSA,
- 12:36the Infectious Disease Society of America,
- 12:38there's no relationship with Lyme and autism.
- 12:40If you look at other studies by Dr.
- 12:42Bransfield published years ago or others,
- 12:44a Richie Shoemaker's group, they will tell you,
- 12:46yes, there is a relationship. When you take down inflammation,
- 12:49the kids' brain get better. But I just spoke to these people in
- 12:52the trenches just two weeks ago in Philadelphia,
- 12:55and I asked them, how many of these kids are you finding have,
- 12:58for example, Lyme and Bartonella,
- 12:59number one in on the MSIDS map,
- 13:02infections, bacterial.
- 13:03They said it's it's like two-thirds of the kids we're seeing now have Lyme
- 13:06and Bartonella. Now, some of this may be transmitted from mother to child.
- 13:09The case that I describe in ending chronic illness,
- 13:12because I've got case studies in the book,
- 13:14right? The case that I had was a 12-year-old boy who was diagnosed with autism
- 13:19spectrum disorder, ~ had all the behavioral issues with repetitive movements,
- 13:23etc. The mother didn't realize she had chronic Lyme.
- 13:26She was a physician, by the way.
- 13:27And when I gave the child dapsone combination therapy to treat the Lyme
- 13:31and the Bart.
- 13:32But ultimately, when he stopped the protocol one month later,
- 13:35the mother called me up and went,
- 13:37Unbelievable, my child. I've never seen him like this.
- 13:40His his brain woke up. He's speaking in full sentences.
- 13:43He's doing great in school. His sports,
- 13:45he can like walk on ropes with balance.
- 13:47She said, I can't believe what happened.
- 13:49So when I talk about these six rivers of inflammation,
- 13:52you you have to realize that even though there are 16 potential factors,
- 13:56and mitochondrial dysfunction,
- 13:58by the way, links them all up.
- 13:59Because in the earlier studies,
- 14:01if you have six rivers of inflammation,
- 14:04all of these factors affect the mitochondria,
- 14:06which affect the brain and the way your neurons work.
- 14:08So when people talk about doing mitochondrial regeneration and giving CoQ10
- 14:13and acetyl-L-carnitine and
- 14:15glycosylated phospholipids and NADH,
- 14:17all the things you do for mitochondria.
- 14:19If your mitochondria are what in called the cell danger response,
- 14:23they're stuck. They've got this ongoing inflammation
- 14:27So the reason we're discussing this framework is it's not a typical framework that
- 14:31most doctors use to look at autism,
- 14:33to look at Alzheimer's, but it's a framework that is supported
- 14:36by really hard peer-review science.
- 14:38~ and similarly, ~ mass cell leaky gut.
- 14:42If you're getting lipopolysaccharide,
- 14:44these inflammatory molecules across the gut,
- 14:46in what it does to the brain is it causes a leaky blood-brain barrier.
- 14:50Early on, we talked about microglial activation.
- 14:53Leaky blood brain barriers, inflammatory cytokines,
- 14:56these are all happening in ADHD,
- 14:58autism, and Alzheimer's. So where is the leaky gut coming from affecting
- 15:02the leaky blood brain barrier?
- 15:03Part of it is the gut brain axis.
- 15:05So those two, the number three and four,
- 15:08the microbiome, leaky gut, very important.
- 15:11so I'm trying to understand now your framework.
- 15:13is it a checklist or a differential diagnosis?
- 15:16Is it a sequence, this and that?
- 15:18And so if a new family sits down in front of you,
- 15:21what do you investigate first in this particular child?
- 15:24it is first of all a checklist.
- 15:26I mean, I'm I want to idiot
- 15:26Checklist.
- 15:27proof this for people. You see complex chronically ill children or adults.
- 15:32And honestly, in my world, when the adults would come in,
- 15:35if this checklist I'm referring to that's on my website,
- 15:37cangetbetter.com, they would come in with 30 out of 38 symptoms.
- 15:40So the question is well, if they have fatigue and they have joint pain
- 15:43and muscle pain, neuropathy and sleep,
- 15:45you have to know the chief complaints.
- 15:47You have to know like what are the big complaints.
- 15:49Is it fatigue? Is it pain? Is it memory?
- 15:52So it is definitely going to be a little bit more challenging in
- 15:55a child that's nonverbal, no doubt about it.
- 15:57But let's say the child has GI symptoms,
- 16:00they're constipated, they have diarrhea,
- 16:02they're clearly in pain. Well,
- 16:04you automatically know in that child,
- 16:06you got to look at numbers three and four,
- 16:08you got to look at the microbiome,
- 16:09and you're gonna have to look at leaky gut intestinal hyperbility and mast cell.
- 16:12Because we know the studies are very clear,
- 16:15even the randomized studies, that if you change the microbiome,
- 16:18Heal the leaky gut, these kids are going to get better.
- 16:20So that's an easy one.
- 16:2260 to 80 percent of autistic kids don't sleep.
- 16:24And and in my world, the adults,
- 16:27every patient with Lyme disease,
- 16:2999% have sleep disorders. Same thing with Bart,
- 16:32right? So you've really got to look for that,
- 16:34apart from the fact that in my chapter in my book,
- 16:37An Ending Chronic Illness, when I look at sleep under L is for lifestyle,
- 16:40every one of the 16 factors also affects sleep.
- 16:43So, you might be surprised like there are young women who are thin
- 16:46who have obstructive sleep apnea.
- 16:48Or who have dopamine deficiencies with restless legs,
- 16:50or there's hormonal dysregulation,
- 16:52they're on autonomic overload,
- 16:54right? It's not just, give melatonin and CBD and knock them out.
- 16:58That's not what this is about.
- 16:59It's about getting to the root cause.
- 17:01But we know in autism, when they looked at those inflammatory cytokines
- 17:05in the brain, IL6, interleukin 6 was one of the major ones they would find
- 17:09on autopsy studies. Well, guess what happens when you don't sleep?
- 17:12That is the most major cytokine that gets increased in the brain with lack
- 17:15of sleep is IL6.
- 17:17And one of the and when you stimulate that switch inside the nucleus,
- 17:20NF kappa B, that is one of those inflammatory cytokine that comes out from Lyme from
- 17:24Bart from mold. And it's, by the way,
- 17:26and it's across the board on chronic fatigue syndrome,
- 17:29autism, ADHD, Alzheimer's, that same switch NF kappa B is turned on,
- 17:33driving inflammation in all of these different illnesses.
- 17:36the mitochondria are your powerhouses.
- 17:38And every organ in your body, your brain,
- 17:41your heart, your liver, your intestine,
- 17:44there isn't one organ that doesn't need healthy mitochondria.
- 17:46So in primary mitochondrial disorders,
- 17:49right, when it's actually passed on,
- 17:50it's the maternal DNA and a lot of these that are passed on.
- 17:53You're looking at, if you look at the organs that are affected,
- 17:56it's the eyes with blindness, it's seizure disorders,
- 18:00right, with problems with it, it's the heart.
- 18:03it's the kidneys with Fanconi syndrome,
- 18:05it's the intestinal. These are always the organs where you need
- 18:08a high mitochondrial functioning,
- 18:10right, for it to work properly.
- 18:11But secondary mitochondrial dysfunction is simply because you've
- 18:14got free radical oxidative stress.
- 18:16your DNA is protected in your body by something called histones.
- 18:19So you've got it protecting the DNA.
- 18:22So if you get all this inflammation and free radical stress,
- 18:24you're not going to damage the DNA as much.
- 18:26But the mitochondria have nothing protecting them whatsoever.
- 18:30And that's why we find mitochondrial dysfunction in pretty much every chronic
- 18:33illness you look at, it's going to be a major player in all of them,
- 18:37including Alzheimer's, where they're now looking at like low-dose methylene blue
- 18:40and mitochondrial supplements.
- 18:42But again, where's the mitochondrial dysfunction coming from?
- 18:45Well, those first six rivers of inflammation.
- 18:48So again, if you use them, I'll give you an example.
- 18:50You use a mitochondrial peptide like MOTS-c.
- 18:53If you still have the rivers of inflammation,
- 18:56keeping your mitochondria in the cell danger response.
- 19:01It it's not going to work. And in fact,
- 19:02it may even make it worse because you're still going to get the mitochondria
- 19:06in the cell danger response. It's not going to come out of it until
- 19:09the infections and the toxins have been dealt with,
- 19:11That's true because a lot of people are chasing this magical mitochondrial kind
- 19:16of regeneration, but the root causes are still there.
- 19:19The fire is still there. You have to deal with the fire.
- 19:22I have three levels of inflammatory biomarkers.
- 19:25The first are ones that are really easy,
- 19:27like sedimentation rates and CRP and VEGF and MMP9,
- 19:31matrix metalloprotonase. I go through these in detail.
- 19:34The second level, lipid peroxide,
- 19:36how much free radical oxidative stress is affecting your membranes.
- 19:39Eight hydroxy de guanine, how much free radical oxidative stress
- 19:42is damaging your DNA. Protein carbonyls,
- 19:45how much free radical oxidative stress is damaging your proteins.
- 19:48That's level two inflammatory biomarker.
- 19:51But the third is when we started the conversation today about checking those
- 19:55Alzheimer's biomarkers with tau,
- 19:57P Tau, serofilament light. A young child,
- 20:01by the way, is not going to get beta amyloid,
- 20:02but what they will see is ~ amyloid precursor proteins,
- 20:06APP, that does show up actually in some of these kids with autism
- 20:10or before getting sick. So you can check,
- 20:12that's level three biomarkers,
- 20:14We talked about these inflammatory pathways that you could have infections
- 20:17and toxins and microbiome issues and vitamin,
- 20:20mineral sleep affecting these biochemical pathways that drive inflammation.
- 20:25But the problem is in just checking these,
- 20:27and you can check them in the blood.
- 20:28They found that they weren't specific for autism.
- 20:31They would find them in ADHD, they would find them in schizophrenia.
- 20:34Well, here's my question for you as a parent.
- 20:36If you had a healthy two and a half-year-old child and you found these inflammatory
- 20:40biomarkers,
- 20:41I personally wouldn't care if it meant my child was going to go
- 20:44on to become schizophrenic, have ADHD or autism.
- 20:46It would say to me, my God, there's a fire going on in my child's
- 20:46Yes. What do we do?
- 20:51body. Where is the fire coming from?
- 20:54Right? So you can't use the biomarkers specifically,
- 20:58these chemokines, cytokines to tell you where the fire is,
- 21:01but it still tells you there's a fire.
- 21:04Some of the invisible ~ downstream factors that I think parents miss
- 21:08the most because they look they look like autonomic dysfunction,
- 21:12POTS, chronic pain, you talked about hyper hypermobility,
- 21:15deconditioning, but also something that's a huge issue with parents
- 21:21of kids and adults with the autism,
- 21:23OCD, extreme anxiety and mood.
- 21:27So in your model, how much of the anxiety and OCD is a nervous system
- 21:32in a chronic threat state rather than a separate diagnosis?
- 21:36you need a vagus nerve that is balanced.
- 21:38If your vagus nerve is twitchy,
- 21:40And hyperactivated, you're gonna have inflammation.
- 21:42You need a balanced vagus nerve.
- 21:43And if your vagus nerve is not working and you're orthosympathetic,
- 21:47like you're throwing out epinephrine and norepinephrine,
- 21:50that's a fight or flight response.
- 21:51So if you ever see a child who is constantly like light-sensitive,
- 21:55sound sensitive, reacting to everything,
- 21:57anxious, you gotta worry that they have an overstimulated autonomic nervous system.
- 22:01Again, why do they have it? You gotta get back to the root cause.
- 22:05We've seen it with Lyme, we've seen it with Bart,
- 22:07we've seen it with long COVID.
- 22:09Right? We've seen it with mold toxicity.
- 22:11All of these things can cause POTS disautonomia,
- 22:13including genetics with Ehlers-Danlos syndrome,
- 22:16you have to feel better to show up better.
- 22:18You have to take care of your health to be able to take care of your child because
- 22:23it's a marathon. So if I turn
- 22:26The
- 22:26map around and pointed to parents.
- 22:28You put ADHD, autism, and Alzheimer's on one continuum.
- 22:32So I've been in some degree, huge degree of hypervigilance for 20 years.
- 22:38So have most of the people listening.
- 22:40So the for the parents in their 50s,
- 22:42exhausted, same inflammatory biology running in them.
- 22:47When a child has these infections,
- 22:49inflammatory factors.
- 22:51What do you actually check also in the mother and and the father too?
- 22:55So you've got to start checking yourself as a parent,
- 22:57as an adult who has to take care of your child.
- 23:00You need to be on top of it.
- 23:02So I do high-intensity interval training seven days a week.
- 23:05I get eight hours of sleep. I stay away from carbs.
- 23:08I keep my weight down. Now my whole family died of cancer.
- 23:11I don't have one person left. Right.
- 23:13So I have a section of my book on cancer,
- 23:15right? Show under the C, C is for cancer,
- 23:17cardiovascular disease, chronic fatigue.
- 23:19I wrote that for my family who's all died of different forms of cancer,
- 23:23showing the same 16 factors underlying cancer,
- 23:26infections, and toxins, and it's the same thing.
- 23:29So
- 23:30As a parent, as an adult who wants to stay healthy and needs to stay healthy,
- 23:34do the MSIDS model, just go through it,
- 23:36but look at the specific symptoms because it's always going to
- 23:39be the chief complaint. And again,
- 23:41in my book, I mean, I could show you this early on.
- 23:44It's like if you find one symptom,
- 23:46it'll tell you what is the differential diagnosis.
- 23:50Like, let's say it's neuropathy.
- 23:51Well, neuropathy could be Lyme,
- 23:53could be Bart, could be B12.
- 23:56It could be folic acid. It could be heavy metals like arsenic,
- 23:59lead, and mercury, it could be mold toxins,
- 24:01it could be carpal tunnel. In other words,
- 24:03what I'm going to teach you is how to do differential diagnosis.
- 24:06How to say, even with one symptom,
- 24:08I want to teach you how to do differential diagnosis and figure out,
- 24:13going backwards, what is causing that one symptom.
- 24:16And then you look at the gestalt of all of the symptoms and you figure
- 24:19out that's how you do medicine.
- 24:20All that love and compassion you poured into your child,
- 24:23do it now for yourself because you need to be healthy for your child
- 24:26as time goes on. And you deserve it.
- 24:27Yeah, you need to be.
- 24:28You need to
- 24:28be.
- 24:28They're younger than you. So do not wait until you have the huge symptoms.
- 24:33Start preventing it. It has to be done at least ten years before the first symptoms.
- 24:38So it's essential. It's not selfish.
- 24:41It's literally life-saving for your child.
- 24:44You have to take care of yourself.
- 24:46so, Richard, can you tell our audience ~ where can they find your book?
- 24:51When is your book coming out? And where can they find you?
- 24:54Can they work with you? tell us everything.
- 24:58you can find my book and about the book at my website,
- 25:01which is www.cangetbetter.com.
- 25:04I do have a medical detective substack that is free to sign up where I
- 25:07do a weekly Substack on like updates in medicine of anything
- 25:10I think that's important. And I show people how to think out like difficult diseases
- 25:15or
- 25:16diseases where something may have appeared,
- 25:18but it might be due to something else.
- 25:19So that's free to sign up.
- 25:21Well, now I would love to end the way I end every episode here on biohacking autism.
- 25:26Richard, if I'm giving you this magic wand and you're looking at
- 25:30all 16 factors ~ in the mother and the child,
- 25:36if that became a standard care for autism,
- 25:40but also for all the chronic diseases and Alzheimer's,
- 25:44and if it was taught.
- 25:46in every medical school and sitting now the book is already not just for Christmas,
- 25:51it's sitting on every pediatrician's desk and what would the world look like
- 25:56for people with autism and the people who care for them?
- 25:59these chronic disease epidemics that we talked about earlier,
- 26:01where so many people are tired and achy and have pain and neuropathy
- 26:05and brain fog and mood disorders,
- 26:07we would find a lot healthier planet.
- 26:09We would not be dealing with all of the illnesses these chronic fatiguing,
- 26:12musculoskeletal, neuropsychiatric illnesses that are
- 26:15now overwhelming the population.
- 26:18So I do think we would have a much healthier and happier planet because chronic
- 26:22inflammation is underlying all this chronic illness.
- 26:24And, we're in a very precarious situation right now with all the infections that
- 26:27are spreading and all the toxins getting in.
- 26:29We need a major paradigm shift in the way we do medicine and getting to these,
- 26:3416 root causes, changing the paradigm that it's not one cause,
- 26:38one disease. It's not name the disease and throw the drug at it,
- 26:40which is driving up healthcare costs.
- 26:43I think we're gonna have a lot healthier and happier population
- 26:46and people living longer
- 26:47I'm sending this vibe to you. I'm hoping that Dr.
- 26:51Horowitz's work can be validated and scaled very quickly.
- 26:55And that would definitely help us parents of kids with autism so much.
- 27:00And Richard, thank you so so much for this conversation.
- 27:04And what I take from it again is that diagnosis is just a label and a label
- 27:09is not biology.
- 27:13Correct. One hundred percent in agreement.
- 27:14Thank you, Richard. ~ I'm Nadia Elkhatib and this is Biohacking Autism.
- 27:18And if this gave you a better set of questions to take to your next appointment,
- 27:23share it with another parent. Somebody out there is at the very beginning
- 27:28and have no idea where to start.