1411-RelB/ILF2–GM-CSF Loop Sustains Cancer Immunosuppression

Paper Talk · Aug 10, 2026 · 22m

This research study identifies a specific biochemical signaling loop that drives prostate cancer’s ability to evade the immune system. The authors demonstrate that the interaction between two proteins, RelB and ILF2, stabilizes the expression of GM-CSF, a cytokine that recruits and activates myeloid-derived suppressor cells (MDSCs). These MDSCs create an immunosuppressive environment by inhibiting the activity of anti-tumor T cells, effectively shielding the malignancy from natural defenses. Crucially, the study suggests that blocking the RelB/ILF2 complex can decrease MDSC populations and…