335-TSC tunes Cortical Progenitor Balance and Neurogenesis
The study details how the Tuberous Sclerosis Complex (TSC) proteins regulate the balance of progenitor cells, specifically radial progenitors (RG) and intermediate progenitors (IPs), during neocortex development. The research, primarily using mouse models (TSC1/2 cKO), demonstrates that the loss of TSC proteins shifts this balance toward an increase in IPs, leading to the overproduction and aberrant organization of upper-layer neurons, resulting in cortical expansion and malformations. Furthermore, the study suggests that the evolutionary suppression of TSC protein expression via human-gained…
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