1051-CAR-Monocytes for Cardiac Fibrosis Clearance

Paper Talk · May 30, 2026 · 24m

This research describes the development of pleiotropic chimeric antigen receptor-monocytes (pCAR-Mos), an innovative cell therapy designed to treat myocardial infarction and prevent heart failure. By engineering monocytes to target fibroblast activation protein (FAP) and secrete the regenerative protein Agrin, researchers created a dual-action treatment that simultaneously clears pathological fibrotic scarring and promotes the growth of new heart muscle. Unlike previous CAR-T or CAR-macrophage therapies, these engineered monocytes demonstrate a superior ability to migrate to damaged cardiac…