634-The GPX1-OSBPL8 Axis: Pathway for In Vivo Ferroptosis
This research identifies a noncanonical ferroptosis pathway that occurs naturally in vivo and is driven by reactive oxygen species (ROS). Scientists discovered that the protein GPX1 serves as a specific shield against this process by reducing oxidized phosphatidic acid, a type of lipid damage that accumulates in the endoplasmic reticulum. Unlike the better-known GPX4-dependent pathway, this mechanism is triggered by high internal stress rather than external chemical inducers. The study reveals that GPX1 must interact with a secondary protein, OSBPL8, to be properly recruited to cellular…
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