Are You Highly Sensitive? The Neuroscience of Rejection Sensitive Dysphoria, 12 Signs You Might Have It and Why Logic Won’t Fix Emotional Pain.

Mayim Bialik's Breakdown · Mar 20, 2026 · 52m

This might be the most vulnerable episode we’ve ever recorded.

No guests. No buffer. Just Mayim and Jonathan…and something we didn’t realize was quietly shaping Mayim's entire life!

We’re talking about Rejection Sensitive Dysphoria (RSD) — and what started as a casual conversation turned into a full-blown personal reckoning.

If you’ve ever:

- Felt physical pain when you thought someone was disappointed in you

- Spiraled for HOURS (or years) over one tiny mistake

- Assumed you were getting fired every time your boss said, “Can we talk?”

- Left parties early because you were sure you didn’t…