Latest / Ageless and Timeless Podcast® / Elizabeth Yurth, MD is Co-Founder and Chief Medical Officer of Boulder Longevity Institute

Transcript

Elizabeth Yurth, MD is Co-Founder and Chief Medical Officer of Boulder Longevity Institute · Ageless and Timeless Podcast®

0:09
Good afternoon everyone. This is Michelle Hughes from Ageless and Timeless. Well,
0:14
I have a wonderful guest today. I always say this because I always get
0:18
the best guests that are in on my radar, and doctor Earth is our
0:24
guest today, doctor Elizabeth Earth from Boulder, Colorado, and she's one of
0:28
the co founders of the Longevity Institute, which she's going to tell us about
0:33
in just a moment. But I just want to say that the reason that
0:37
I've invited doctor Earth is because I had looked at I always look at the
0:43
podcasts of other posts just to see if people are focusing on some of the
0:49
same subjects that we think are important. And one of those, as you
0:53
all know, I've been doing several podcasts on peptides, and I noticed as
0:59
I look through the various podcasts on YouTube and on Instagram and so well you
1:07
mostly YouTube, I found that doctor Ereth was a real expert in peptides.
1:11
So we're going to talk about peptides today, but in the beginning, I'd
1:15
like to get an overview and so you can understand who she is and what
1:19
she does and why we think her experience and knowledge is so valuable. So
1:25
doctor Earth. Welcome to Age Lists and Timeless. Thank you, Michelle.
1:29
I appreciate you having me on. You are welcome. I will say I
1:34
came to this in a very roundabout way because I came from an orthopedic background,
1:38
and most orthopedes want nothing to do with medicine. In fact, one
1:41
of the reasons I left my orthopedic group finally after thirty years almost was the
1:47
comment that when somebody asked why I was ordering labs and looking at all hormones
1:52
and things on my patients, I said, you know, I said,
1:53
well, because that's all part of healing. And they said, you know,
1:56
we don't do medicine here, we do orthopedics. So you know,
2:00
Unfortunately, Orthopedix was a little bit in the sort of backwoods as far as
2:05
the longevity medicine goes. And so I about seventeen eighteen years ago, now
2:12
having practice with peaks for a long time, was sort of frustrated with the
2:15
we'd patch people together, they'd come back never really quite being one hundred percent,
2:20
and we'd patch them together, and then come back, we patch them
2:22
together, and finally you'd replace the joint whatever, and we really felt like
2:25
people never truly got healed, and so I started to look at can we
2:30
actually make people truly heal? And that was going to entail looking at nutrients
2:36
and looking at exercise and looking at hormones and because that's such a neglected piece
2:42
of us being able to heal from injuries. And so as I started to
2:45
learn more about this, I thought, gosh, I gotta go learn more.
2:46
And this was back you know, I know you're you're a big part
2:50
of a forum, and it was a big This is back when a forum
2:53
was really a small group of doctors. It was you know, Steen years
2:55
ago, there was not very many people in the crowd. Now it's grown
2:59
a thousands, But it went sort of searched it out as the place to
3:02
learn more about hormones and functional medicine. And so I went into a fellowship
3:06
through a four m and then I've sort of wore two hats. I practiced
3:10
at my orthopedic clinic during the day, and then I had vote Longevity Institute
3:15
in the evenings, and I would come and see patients here in the evenings,
3:19
and I would sort of try and do my fifteen minute appointments in orthopedics
3:23
and not tell people everything, just try and get them at least introduced to
3:25
it, and then people could find me here if they wanted and come and
3:28
see us here. So then about two years ago, now I really said
3:35
I can't wear both hats anymore. And so we brought the orthopedic practice into
3:38
vote longevity Institute. So now the clinic is actually, you know, we
3:40
deal with the whole body with everything getting well, but a lot of people's
3:45
come to us from an orthopedic perspective who aren't doing well, who aren't or
3:49
who have cute injuries we deal with. We're in Bolder. We have a
3:52
lot of athletes. We have a lot of very high level athletes, so
3:53
you know who want to get better fast. You know, they need to
3:58
get better fast, so trying to give them rule to be able to recover
4:00
more rapidly. And a lot of them are really when you look at these
4:03
high level athletes, a lot them are very much challenged hormonally, they're overtrained,
4:09
things like that. And so we combined the whole longevity health piece into
4:14
the orthopedic piece, and you know, at least like a whole jius and
4:17
you know, want regenerate procedures on a knee or something like that, but
4:19
for most part we try and get people into the paradigm. If you get
4:24
yourself healthier and focus on the joint as a part of that health, that
4:30
the joint will follow. That I got here that is such an important piece
4:38
because so often, as you said, athletes haven't focused on the anti aging
4:44
or the longevity aspects. So what happens when an athlete is seriously injured and
4:49
you want to introduce them to all the techniques to get better faster that are
4:55
part of the regenerative medicine practice. I think that that's tough because a lot
5:01
of the athletes have you know, they're familiar with things like peptides, right,
5:04
so a lot of them have been in the reading and they read about
5:06
BPC one fifty seven, which is a peptide that really helps with healing,
5:11
and they've bought it online from some research chemical place, and so you know,
5:15
they've sort of touched on some of these things. They've done reading,
5:16
they've looked, and so some of those things have circulated around. One of
5:20
the problems with peptides in the professional athlete world as they are all pretty much
5:26
banned, so you have difficulty with that. But in the more amateur athlete
5:30
world. They would search these things out and find them, but they would
5:32
you be using them relatively and appropriately, sometimes from sketchy sorts and sources and
5:36
things like that. But so let's say somebody comes into us they've just had
5:41
a anti a crucial ligament tear in their name and it's been surgically repaired,
5:46
and they told him it's going to be you know, nine months before you
5:49
can get back into your sport. Well, so our goal is, how
5:51
do we number one, hasten that process, but number two make sure you
5:57
actually get into your sport. I think a lot of people don't know that
6:01
even something like an ACL tear and I tore my sales four times too on
6:04
each knee. You know, an ACL tear is not simply oh, you
6:10
fix it and you're better. In fact, eighty percent of people who have
6:14
who tear their a cl and if you're sixteen when you do it, are
6:15
going to have austarthrised by the time they're fifty. So we know that something
6:19
starts in that process, and if we don't nip that in the bud,
6:23
then these people are going to go become debilitated. And I can tell you
6:26
I'm you know, tour my first ACL sixteen and subsequently more and more after
6:30
that, and finally didn't even repair them because I didn't it wasn't working for
6:34
me. And my knees were are horribly arthritic, but because of what I
6:40
do, they have zero paining and I'm totally functional. I can do everything,
6:42
even though if an orthopedic surgeon put on my knee X rays, they'd
6:45
say, oh my gosh, you just need these replaced, but I have
6:47
no pain, totally functional and hopefully regrowing cartilage. So basically, let's say
6:51
you come into me, you turn your ACL, your surgeon fixed it,
6:55
you want to get back. One the first things you have to do is
6:59
number one, make sure that there's the hormones on board to help joints and
7:04
ligaments heal. So you know, I know you've talked to some of your
7:08
guests about hormones, and I think one of the things we forget is how
7:12
imperative hormones are in both men and women to healing an injury. For ligament
7:17
healing, you need to have estrogen on board, you need to have progestern
7:20
on board. This is men and women. So when you look at these
7:25
athletes who are oftentimes overtrained, and they they are hormones like a lot of
7:30
them, their hormones are not very good. You need to make sure that
7:33
is all optimized. And the next step you always have to do with these
7:38
people is basically teach them that what happens when you have an injury, just
7:45
like a viral illness, Like let's use our favorite virus for example. So
7:48
basically, you have a viral illness and your body is supposed to react to
7:53
it. You're supposed to get a fever, you're supposed to, but if
7:55
it sticks around, that's a problem. So if inflammation comes and just stays,
8:01
that's a problem. Right. What we want is a little inflammation.
8:03
We want to go away, and we don't want to start healing. But
8:07
most of us maybe don't have all the nutrients we need, or maybe our
8:11
genets are just as such that we get this escalation of these inflammatory proteins and
8:16
instead of going away the way they should, they basically stay elevated. And
8:22
when they stay elevated, right then and there you start destroying cartilage. So
8:30
we'll use things that will actually blunt some of those bad proteins and some of
8:35
the bad enzymes that have started destroying your cortilage right there at that time of
8:39
the entry and those things, what are they? So one of our favorite
8:43
go tos is actually what's called it's called a repurpose drug and something called pentisin
8:48
polysulfate, So pensin polysulfate, which is coming to the US as the drug
8:52
xylasol, been used in other countries for quite some time. Here in the
8:58
US, we have an oral version of it. It's called elmron. It's
9:03
used for bladder inflammation. So the oral version for bladder information, however,
9:07
has two problems. Number one, you have to use a relatively high dose
9:11
of it to get efficacy. And number two, what they found, and
9:16
theyve been using strugs since the fifties for bladder inflammation for like women, was
9:18
a stias from menisisdidas. What they found is about they're just starting to see
9:22
these cases now, so you know, years and years later, but cumulative
9:28
doses of this drug at a high dose, people started to developed this weird
9:33
retinopathy so damage their eye that was irreversible. And so the drug penison polysulfate
9:39
or el moron actually has a black box warning about it. But what we
9:43
know is that as a different drug called xylosoul as an injectable subcutaneous. You
9:50
can microdose it, So just like microdos and all those other things you hear
9:52
about pulocybins, you can microdose the penison polysulfate, so you never reach those
9:58
threshold dorus doses that cause the retinopathies and likely the subcutaneous injections. At this
10:03
point, it looks like don't even cause that even even over long term.
10:07
U so zylesall's in phase being pushed through rapidly. Phase three trials here in
10:13
the US are doing a big, big study with NFL football players XNL football
10:16
players on it. It will probably come to market in a few years,
10:20
but we've been using it for about three years because because it is a drug
10:24
that's available as an oral form, we can have a compounded count, compounding
10:28
pharmacy very easily make it into a loto subcutineous injectable form. So how do
10:35
you compare that with BPC one fifty seven, which has no side effects?
10:39
And are they doing the same thing or yeah, so BTC is great,
10:45
right, So BPC by protective compound works very differently. It's it is.
10:50
It is great for healing and I'll use it in concert with penison, but
10:54
pentison in the studies and there's nothing else that does this over a period of
11:01
time. They just released the year follow up on this drug in March that
11:07
they saw thirty seven percent improvement in cartilage space on knee X rays. Ninety
11:11
percent of people had substantial improvement in art thirty paint. These are people who
11:15
are actually handed to joint replacements no complications. The group, the placebo group
11:20
had loss about four to ten percent loss of cartilage space. And again,
11:26
you know, when do you see improvement cartilage space, You just don't.
11:28
EPC is not going to help you to regrow cartilage. EPCY is very anti
11:33
inflammatory, it helps repair. It's better for soft tissue than it is for
11:37
joints, so works better for soft tissue healing, so like tenoniasis, things
11:41
like that. But when you're looking at joint arthritis, it doesn't do some
11:45
of the things you need, particularly when you look at propagates after you tweak
11:50
your knee, you have an injury, What propagates your body starting to destroy
11:54
the cartilage are an enzyme called mattellmatex protise three MMP three. I always like
12:01
to think about MMP three sort of like, um, it's it's coming in.
12:05
It's the guy you get to come and clean up a mess, right,
12:07
So mess, You've got to have somebody to come clean up the mess.
12:09
So it's coming in. You've got all these these dead white cells from
12:13
the inflammation. It's trying to clean up the mess. The problem is much
12:18
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13:09
So but doctor, can you in any of these protocols, can you
13:13
help the athlete to avoid a surgery if you have a complete ACL tear my
13:22
feeling and I know there's some regenerate of doctors who disagree this thing you can
13:24
really regrow. I think if you have a complete ACL tear, you should
13:28
fix it surgically and then follow that with a mechanism with a treatment plan that
13:35
keeps you from progressing to oarthrias. Now where we can avoid surgery and where
13:39
I think we will see. You know, when you look at this drug
13:43
that's been used in Australia now they reduce the need for joining places almost ninety
13:46
percent. What we will see is that we can really dramatically change people's course
13:54
to a JOIT replacement. I mean, you know, there's people who are
13:58
just too far on, you know, But if I can catch you at
14:01
an earlier stage, if you're at it like a stage three arthritis, you
14:05
know, so you're severe, you have a lot of pain. The only
14:09
answer is a joint emplacement. But there's still a little bit of work to
14:11
work with. You're going to do great with Kennison. So that's where we
14:15
can really avoid surgery. If you have an acute or a meniscule tear.
14:18
For instance, meniscual tears should ever be you should not have surgery on a
14:24
meniscal tears unless you're twenty five years old or twenty years old. In fact,
14:28
in every other country, surgery for a meniscule DJed a meniscal tear is
14:33
banned. You can't even do it because it's been shown to be such an
14:37
ineffective surgery. And now here in the US it's one of our number one
14:41
surgeries. Going in there. You know, you tear the meniscus, you
14:43
go in, your knee hurts, you tear a meniscus, and the docks
14:46
like, well, let's just we'll go clean that up, you know.
14:50
And I always tell people the old let's just clean up your knee. That
14:54
like your dementia patient coming to you and the doc going, let's just go
14:56
in there and we'll take out those badges. Right, it's half the same
15:01
scenario, so where we can avoid surgery as degennal miniccipal tears, ostars wires
15:07
progressing to joint replacements. I think if you have a complete rupture of a
15:11
ligament, putting the ligament back together still important. Reconstructive work and what do
15:16
you think about titanium When you break let's say an ankle or your foot and
15:20
you need to have titanium screws and implants. So what's your thought about titanium?
15:28
Is it a good solution, is it a long term do you need
15:31
to eventually have it taken out? And I think typically we're going to have
15:37
to use hardware. You have a fracture, You're going to have to use
15:39
hardware to fix a fracture, right, you know, so if the fracture
15:43
needs to repair, even have to use hardware. In general, titanium is
15:46
pretty benign. There are people who have reactive changes to things, right,
15:50
So there are people I see who have inflammatory changes to almost everything you do.
15:54
And we see a lot with joint replacements, people who have nipple allergies
15:58
for instance, things like that with joint places. But even titanium, which
16:00
is probably the safest of the metals that we can use, you do you
16:03
see people who have reactions right that come in and they have a lot of
16:06
pain, and they have a lot of inflammation, and you can actually run
16:07
some some labs on them that show that they're having sort of an immune reaction.
16:11
Here to the hardware um, A lot of times we end up taking
16:15
the hardware out most people anyway, simply because the hardware itself is sometimes painful
16:19
and there's no reason after a certain point to have it in there. It's
16:22
a lot of times that anyway. M Well, let's let's jump over to
16:27
the regenerative side, because there's so many subjects I want you to focus on
16:32
with our viewers today, and I know, well before I know, it
16:36
will run out of time, So let's just talk. Let's talk generically about
16:41
aging. What what is aging? And why is it important? Or is
16:45
it a disease or what what? How do you define the term aging?
16:51
Let's talk first about that and then about biological versus chronological aging. So I
16:56
know you've talked to I know you had Ryan Smith on recently who talks a
17:00
lot about, you know, measuring biologic age, which is chronological age.
17:04
So when you look at aging, I along the probably most people that you've
17:08
talked to in our field consider aging and disease. Right, it is basically
17:15
that everything that kills us cancer, heart disease, kidney disease, dementias,
17:22
those are all higher. They get higher and higher as we age. So
17:26
ultimately the disease we're trying to treat is aging. We're trying to to not
17:30
see this organ system decline. And there's a universal problem at you know,
17:37
at a cellular level when you look at aging. I think this is what
17:41
when you look at functional medicine, where it says, okay, well you
17:44
know, um, you're fatigue, let's look at the adrieum glances. You
17:48
know. So I think that that's that functional medicine is becoming a little bit
17:55
now the way traditional medicine was. It's gained a little behind the scenes.
17:59
So myself, I'm on faculty with a group called SSRP or see Scientific Research
18:04
and Performance, and we're trying to teach a new kind of medicine called cellular
18:07
medicine when you actually look at the function of the cell and what's going wrong
18:11
at the cellular level that's promoting all of these disease processes. And it can
18:17
really come down to some very basic things. Number one is mitochondrial dysfunction.
18:22
So our mitochondria don't they stop working well? Right if you think about the
18:26
tissues that are the most dense. Remember all your listeners, mitochondria you learned
18:32
in high school, they're they're Basically, the energy have powerhouses of the cell.
18:36
They make all your ATP right, that's right. Going as the older,
18:40
we get less mitochondria, and we also get more dysfunctional mitochondria. We
18:44
get more damaged mitochondria, and that screws up the balance we have was called
18:49
redox is balanced between reductive nats and oxidatus species, and basically once that balance
18:55
gets screwed up, you start screwing up a whole lot of down things.
18:56
So almost every disease can't or heart disease, brain disease, you can link
19:03
to mitochondrial dysfunction. The tissues that are most mitochondrial deaths that use the most
19:08
energy or your heart is skeletal muscle in your brain, so those tend to
19:11
go sometimes more rapidly than other organs. Right. One of the first things
19:15
you see when people age is they become sarcophenic. They start losing muscle.
19:18
One of the reason is that they're getting this mitochondrial dysfunction and the muscle.
19:23
You can't get energy to the muscle. So we really look at trying to
19:27
repair this sort of the cell at that level and then the other piece,
19:33
and this all kind of ties back to the cell is that once you start
19:37
disturbing all these processes, you actually start getting immune dysregulation. So you'll see
19:42
is that there's a hyperimmune state where the body is not learning to attack things
19:48
like viruses anymore, that is attacking yourself. And so we know this dysfunction
19:53
or loss of immune function is a big piece too. If I look at
20:00
any disease, I start with looking at mitochondrial function what's called proxysomal function,
20:07
because those are the things that help you make energy. It's a very cool
20:10
test that most people don't know about, designed by one of my good friends,
20:14
Sartre Dane good Now, who if you can have on the program,
20:17
you should because he's incredible. He wrote the book Breaking Alzheimer's and he is
20:22
one of the most expert biochemist'll ever speak to, but can actually speak like
20:26
a normal person. And he signed a test that's one of the only tests
20:33
that we can utilize to look at where the cell is failing. So we
20:36
kind of call our systems checked for the cell. What's going on with the
20:41
mitochondria, what's going on with the cell membrane, what's going on with the
20:45
mile, and what's going on with the proxysomes that again helping carry fatty acids.
20:51
So we can actually look at these very specific fatty acids and lipids and
20:57
decide exactly what's going on with the cell. So just like you, just
21:02
like your car or somebody, you can take it into a system's check.
21:03
Right, you don't want your car to be in the middle of the desert
21:07
now it just all dies. So basically, if you can catch those things
21:11
early, this is way before they present with any diseases a lot of times,
21:15
right, then we can we can fix them. We can fix the
21:18
mitochondria, we can fix the proxim but a lot of that is repairing,
21:22
is repairing, you know, repairing the cell at it's a very base level.
21:25
It's that a blood test that you do have a blood call. Yeah,
21:27
it's called a prodrome scan prodrome. How does that compare with what true
21:33
diagnostics with Ryan Smith does with the DNA methylation and telomeres, so so very
21:40
different. We're again trying whereas you know, the problem I think with a
21:44
lot of the um aging tests is you get back this number, right and
21:48
they say, you know, and I don't know if you've gotten one,
21:51
but you know, you say oh, you know, these people get these
21:52
old oh god, I'm five years older than my chronolocka age, and you
21:56
know, and then you look at their little recommendations which is like eat more
22:00
fish, exercise more, you know, and you're like, I'm doing all
22:03
that now what this doesn't make any sense? Right? And I get that
22:04
all the time, like people who look an optimal health and they're great,
22:07
and then they come back with this number on methylation age that that doesn't fit.
22:12
I don't know what to do with it, right. We have to
22:15
have some answer to what to do with that. So I think, and
22:18
particularly I think that you know, um, doing it in rate of aging
22:22
is probably more important than methylation age. But the but I think that those
22:26
those numbers are somewhat important. And doctor doctor Gooden now will argue that we
22:32
actually don't quite know when we're measuring things like that what we're measuring. So
22:37
should my DNA methylation look the same at you know, at sixty two as
22:44
it did when I was twenty? Should it look the same? Is that
22:47
ideal? Or have there been cellular adaptive changes have occurred? They're actually benefiting
22:52
me, right for basing this number on Okay, this is what it should
22:56
because this is what it looked like then as opposed to me, maybe there's
23:00
adaptive changes that are that are good for me. They're actually what's keeping my
23:06
cells a little bit more functional. Right. So there's a lot of things
23:10
we don't know, and I caution your listeners to just go, oh,
23:11
methylation age is everything. I don't think we have that answer. Um.
23:15
I think the answer is going to calm down to more when we when we
23:18
get some of the combinations of methylation age, DNA methylation with proteo mix with
23:23
metabolomics. But that test doesn't exist yet, you know. Uh, So
23:27
I caution people, we also don't know that what you're measuring in these tests
23:33
is true for every organ system, right because you know that that's a that's
23:38
a big piece too. So I am not I don't use that test much
23:41
in my clients. I you know, I think Ryan's brilliant, I you
23:47
know, and and have a lot of respect for the test, but I
23:49
don't use it and I don't recommend it in my clients. My goal is
23:52
to make their cells as healthy as possible, and you know, and if
23:56
I am doing that in all likelihood, I am delaying their aging. No
24:02
matter what my DNA methylation age shows. Well, then what I what I'm
24:04
hearing you say is that all aging begins in the cells. And that's where
24:08
we want to primarily the mitochondria, right, which is the right, Yeah,
24:15
that's the that's the heart of the cell, right, and we screw
24:18
that up. I mean, we've shown cancer is the mitochondras is. You
24:21
could take a cancer and if you put a normal cancer cell and you take
24:25
a normal mitochondria and put it into the cancer cell, you'll make the cancer
24:27
cell normal again. So we could transplant normal mitochondria and never cancer cell.
24:32
We could make the normal again. So we know that the mitochondria carrying these
24:33
this information and that's screwing up. The mitochondria is where where things go awry,
24:41
and you know, and so that's when people all talk about for instance,
24:44
NAD. Right, you know you probably heard, Okay, n A
24:48
D drops as we age, and so U and so pump more NAD back
24:52
in and all's going to be well. Giving a big lecture in a month
24:56
on this, because that's so untrue. NAD levels actually don't drop as we
25:00
age, But what happens is the NAD gets stolen away and more utilized by
25:06
old senescent cells and cancer cells and damage cells. They want an AD.
25:11
They upregulate enzymes to steal your NAD right and give it to these bad cells.
25:18
I throw more NAD or when the precursors into the mix, and I
25:22
do. Over time, I'm actually feeding the senescent cells and the cancer cells,
25:26
and your NAD pools, you know, didn't really go up at all.
25:30
In fact, it's been well shown that you know, n AD pools,
25:33
they stay stacked. If you block the enzymes that depleting n AD,
25:37
the ND pools don't change us. We don't make less an a D.
25:40
What we do is we drain more, and it's primarily because of the damaged
25:42
cells. So we have to have to repair at a different level. We
25:45
repair the enzymes are upregulated by the damage cells. Does NAD have any influence
25:52
negatively speaking on estrogen levels when you give supplemental NAD? Yeah? Um,
26:00
well so you know, and remember an AD itself can't get absorbed as the
26:04
cell at all. Some people who are doing n AD, i'd be infusions.
26:07
What happens, So any dare's no way to get through the cell,
26:11
can't get to a cyplus and cell it just floats around the stem, but
26:14
it converts into NMN and n R and then those go into the cell right
26:19
and and particularly an a MAN is then the sort of the precursor that then
26:25
gets into the mitochondria and gives an AD. And then you've got these enzymes
26:29
something called c D thirty eight n MT that are draining. And now if
26:32
I'm draining my NAD stores and feeding in the cells, does that actually are
26:37
you know, affect my my hormones? Well, indirectly, yes, it's
26:41
a pretty downstream effect. Okay, I think, you know, like correcting
26:45
the NAD in and of it self. But when you're interesting, when you
26:49
do blockers of the enzymes that are stealing the NAD, you do see people's
26:55
hormones stabilize. You know, I took NAD one time I V and boy
27:00
I never get ill, but I got it really affected me, Like I
27:04
had to tell my the doctor, I think I'm getting like nauseous. Why
27:11
why is that? What is it pop? Because it initially creates this big
27:17
inflammatory response. Um, so you get this actually big inflammatory response. Some
27:22
people like that, that's what it's sort of like feel hot and they feel
27:25
so they feel like they're gaining all this energy. It's actually this release of
27:27
all these what we call damage associated proteases or proteins UM damps and pamps,
27:33
these proteins that get released acutely when you release the DNA the NAD. So
27:37
there's an inflammatory response now that usually goes away, but that's not a good
27:45
thing. And you know, and and people have sort of misinterpreted that I
27:48
felt all this energy surge hot and red, and you know, and and
27:52
sort of like exactly, um, you know, and and and yet and
27:59
again, if you do one in ad infusion, you're probably fine. But
28:02
if you keep doing these infusions, you you know, and I can well
28:06
show people how you are feeding cancer when you do that. It's it's not
28:10
a good thing to do. So this is the whole understanding of sort of
28:15
this balance in ourselves. And we can't just say, oh, this is
28:19
getting lower, let's fix let's put all this in and all be well.
28:23
It doesn't make sense. You've got to change the pathways that are creating the
28:29
problem. The pathways have gotten disrupted as we age, right, and then
28:33
I'll say the saying it's tru about d methylation. Some of those changes may
28:38
not may maybe changes that are occurring to help us a little bit right,
28:44
that they're actually trying to deal with some of these stressors that it sees happening.
28:48
So is it necessarily a bad thing? Nobody really knows the answer to
28:52
that. Why do you need to take a precursor? Like, it's the
28:56
same question I have about five HTP and trip defense. I mean, why
29:00
do you Why can't you just take NMM and and trip defend as as two
29:04
examples of the end result of the precursor, So you can't. N is
29:11
a much better way to replace NAD than getting any D infusions because NMN has
29:15
a direct ability to get inside the side applies move into the nucleus. But
29:19
again you still what happens now is that any excess, So your body uses
29:25
what you can. Then if you keep feeding it M it's called the salvage
29:29
cycle, so it forms nikotinomy. Okay, nixty months designe to go back
29:33
and form more n A D, but my NAD stores are already full.
29:37
Nicktine doesn't go that pathway and instead NI nicktinemie needs to get excreted. M
29:45
hmm. It's because of your body's like, oh I've got too much NAD.
29:48
I don't need it. You know, you keep feeding nmn in okay,
29:51
an a man's raising NAD levels. Now it's gotten too much NAD inside
29:56
the inside the mitochondria for instance, and now the end the the men turns
30:00
into nicotinomy I designed to recycle make more n a D if you need it.
30:04
If you don't need it, it's unexcreted. It'll get sexcreted, but
30:08
excreted by an enzyme called n n mt H and n which is which is
30:15
a nice in my tram metal transferrace enzyme, So nn mt is it's very
30:22
upregulated in a couple of cells. Number one is fat cells, Number two
30:26
is cancer cells. They love n n mt M. So when you upregulate
30:30
n n mt because you've given so much n D precursors or NAD and I
30:36
have too much NICOTINEMI now your body is trying to get rid of it.
30:40
Then basically what have I done. I'm now feeding cancer cells and I'm feeding
30:45
fat cells and making people more obst or meta box then sound. In fact,
30:48
if you look up n n mt blockers, they're one of the big
30:52
research places that we're looking for cancer because if you block n an mt,
30:56
you actually can stop cancer. So we're feeding and an mt into these cells,
31:02
right, try and get rid of it. But it's not it's now
31:03
you up bring it so much that your body is feeding it into the cells
31:07
you don't want it to. That is so important what you're saying. And
31:11
I don't think I know nobody knows it. Nobody knows that everybody's out there,
31:15
you know, preaching to take these NAD precurses. Nobody understood. And
31:19
that's what we're trying to to sort of teach is um is with a cellular
31:26
medicine, is you know, understand these pathways. Because the only way to
31:30
not know that you're to know that you're not doing harm and that you're actually
31:33
doing some good is to know these pathways. So what do I do.
31:38
I use n an MT blockers, right, So I so basically, if
31:42
I want my NAD to stay where I want it, I don't want to
31:45
form and what I use is one of the really good So it's all getting
31:49
a little too biochemical. But but the nice cinamide can turn. It can
31:56
either go into a bad product of screwup methylation, or it can turn to
31:59
a good product called one methyl nicotinic gas it or one MNAM and one MNA
32:06
is basically really good for us. It helps, but it makes more metabolically
32:09
sound, increases our searching. It's really good, right, So if we
32:14
could just get one MNA without turning on n nmt So what we do is
32:20
and there's only one place to get one MNA and that's from a company in
32:22
Poland. So we've been working for the past two years um with a company
32:28
that to bring one MNA to the US M to US market because it is
32:32
truly you get all the good sides of the NAD from the one m and
32:37
A it does all the same things walks the nn mt ZI. So you
32:43
reduce cancer, you do so obesity, you do all the bad stuff,
32:45
you improve methylation, and you don't have to go stick a bunch of too
32:51
much NAD you know, into cell and have no idea what you're doing.
32:53
So that's where that's the way I understanding these pathways works. So we had
32:57
to search a long and hard to find a product somebody who made this,
33:00
like we wanted one MNA right and and interesting in this company in Poland who
33:05
makes it was trying to bring it to the US as a drug and and
33:08
you know, and we're like, you know, you are going to take
33:13
ten years to get there. Let us bring it as a supplement. So
33:15
we've we've now kind of so we should actually have that supplement here in the
33:20
US available hopefully for the next month or so. Oh that is, it's
33:24
very cool. And you know, this is a natural part that our body
33:28
makes. It actually is going to be sort of an answer to this problem
33:30
and probably a good thing for preventing cancer or preventing obesity. And you know,
33:35
I think it's a really interesting on a different subject, but the same
33:38
thing I found when I was researching hair growth because as I was getting older,
33:45
I was noticing what a lot of women or men and men of course
33:49
noticed. And I found the DHT blockers and I thought, wow, this
33:52
is and and sought palmetto right, right, oh, this is the answer,
33:58
right, And then you realize all just us levels dropped dry. Right,
34:01
It's true because I had a I have a very high testosterone for a
34:06
woman. I've always been told that I'm way up, and then this last
34:08
blood work was lower. Yeah, and I think it's because I've been taking
34:13
these dh sheet blockers. That's a problem, right, I mean, yeah,
34:16
I mean, you're right, it's a problem for men too. Um
34:20
is the upside if you don't lose your hair. The downside, as you're
34:22
you know, when you completely block DHT, that's your animal cormal and I
34:27
mean that's what makes muscle. Right. Yeah, so it does help.
34:30
What they've shown is very low dose finasteride. So using a very very low
34:34
dose or using just a topical finasteride topical finaster you get less of that effect.
34:38
But I have the same problem. I mean it's like I don't like
34:40
to block my testosterone and yet you know it works great for helping hair off
34:45
exact how you've got to kind of a yeah, right, you're right,
34:51
we do something that's affecting another pathway. And I will tell you, guys
34:54
don't get told this, right, They don't get told you know, by
34:58
their their They go to the doctors they're losing their hair, and he puts
35:00
them on finasteride, right, Yeah, And nobody tells these guys that finasteride
35:05
is going to completely you know, screw up your rotis trusting, yeah,
35:09
and your sex drive's going to go down and your muscle building. And some
35:13
guys and I have like a twenty some year old, it becomes a permanent
35:15
issue. You can't reverse it. It's called finasta from you know, post
35:19
finasterides the room, and it's a hassle when it gets when it happens.
35:22
Well, so you've touched on so many topics. I want to focus on
35:28
two very important ones and that well three actually one is bioidentical hormones, the
35:34
second is peptides, and then the subset of peptides would be the bioregulated peptides
35:39
out of doctor Kavnson's lab and Saint Petersburg. And then the third is kind
35:46
of maybe summing up our talk today is um skin aging because I you know,
35:52
I'm an avid reader, and I tell you, I go on the
35:55
internet and it's every other Internet site is about skin laxity or losing collagen,
36:04
and there just seems to be so many dead ends, and very expensive dead
36:07
ends. So can you just take those three subjects and give us a little
36:12
dissertation on each. Yeah, I think starting with of course, start with
36:16
biodentical hormones. Um. You know, so so my belief and not everybody
36:22
agrees with this. So I we have this course called Human Opfisation Academy and
36:28
it we have this what to fix first, because I would have all these
36:31
people coming to me, you know who, you know they're Dave asked me
36:36
about biohackers, right, and it literally had four pages of biohacks they were
36:39
doing. And they still felt horrible. And I said, well, your
36:42
hormones are still shitty. So you know, let's start there. You know,
36:46
I know the debate as well, do you start with sleep and nutrition?
36:51
I actually will say that lots of times when I have, for instance,
36:54
you know, a menopausal woman come in, or you know a guy,
36:58
you know, a fat guy who can't get into the gym. For
37:00
me to just say you just got to get to the gym and eat better,
37:04
it's just not going to go over exactly. Basically. You know,
37:07
if you're a menopause a woman, there's no progesteron, no testosterone, and
37:10
I'm telling you to sleep, you know, get a good eight hours of
37:14
sleep and go to the gym. You can't. You're like, I can't,
37:17
I can't, I can't sleep, I can't get another gym. If
37:20
I go to the gym, I don't wake it mad any muscle anyway.
37:22
It's disappointing these people and then they get fat, and they feel more and
37:24
more miserable. So I usually start with looking first at you know, and
37:30
again at the age, but looking first at hormones, getting those to a
37:32
point where you know they're at an acceptable range that now I can sort of
37:36
start getting that person they're in a receptive state. Well, I could say,
37:39
okay, now you've got progestertion on board, you should be able to
37:43
sleep a whole lot better. Let's get you into a good sleep routine.
37:45
You've got testosterone and estrogen on board. Now we can get you into the
37:47
gym, and you can actually make some muscle when you go to the gym,
37:51
going and spin your wheels and just getting sore every time you work out.
37:53
So I start there. Now I think there's a sort of this big
37:59
kind of myth and bioidentical hormones, because you know, and the only hormone
38:04
that really is not bioidentical if you get it from a pharmacy versus a compounding,
38:07
is progesterone. Now that's a big Progesterone is not progestine. And anything
38:15
you any of the you know, premarans or birth control pills where those are
38:22
all Progestinsgestins are not identify at all to all Stone, and in fact they
38:30
actually they will have some similar effects on the uterus. The progester receptors are
38:35
on our brain, they're on our joints, they're on our ligaments. So
38:38
basically, if I give progestins, even lowers my progesterone further because now my
38:45
body thinks it's getting something, but it's not the same and it isn't seen
38:50
the same way at all, because it doesn't look anything like my progesterone.
38:53
It actually acts more as a carcinogen. So progestine is very linked to cancers.
38:59
It's not been official. It doesn't help mood disorders, it doesn't help
39:02
joint pain. You know. One of the big causes of joint pain is
39:05
a low progesterone, and so you've got to use bioidentical progesterone, not progestics.
39:10
But people talk about bioidentical estrogens. Estradial is estradial. I don't care
39:15
if you get the estradial patch from your pharmacy, or I compound it for
39:21
you in a cream, or you know, estradial is estradial. There's not
39:25
a different form of it. I think the functional medicine doctors have kind of
39:30
gott into Oh, you have to get this estrogens from the compounding pharmacy aside
39:32
a woman who's cheaper and easier for them to get you know, an estradial
39:37
dot or patch or or you know, cream from their pharmacy. So be
39:42
it. Lots of times it's cheaper for them to get it from a compounding
39:44
pharmacy always, and some women are finding more convenient to use a patch.
39:47
So estrogens are estrogens and testosterone is testosterone. Big difference is that I can
39:52
dose things exactly the way I want them when I get them from a compounding
39:58
pharmacy. Yeah, so I can. I can much more specifically dose it
40:01
is supposed to use. Even this is the doses it comes in right.
40:05
And then usually for you know, for women, there's not really any testosterones
40:09
over the counter for women. They're designed for women, so those they have
40:13
to get compounded. And I always remember because I still see a lot of
40:16
women on oral estrogens, and oral estrogens are the one thing I'm not fond
40:21
of because when we look at the risk of blood clots, strokes, embolic
40:27
events, that's the oral estrogens. There is not one study to show that
40:32
transdermally applied estrogens create any change in blood clot risk or stroke risk or heart
40:37
attack risk. But there is with oral estrogens when they go through the liver,
40:42
they can be damages the liver. They also have an ultrip byproduct that
40:45
affects blood clotting. So I hear this all the time too from the primary
40:47
careacters. I'll put my women on on transdermal estrogens and then they say,
40:52
oh, you know you have a stroke risk, you shouldn't do those.
40:54
And I challenge the doctors show me an article that supports that, and they
40:58
never do, but they still continue to said. So you know, you've
41:00
got to look at scientific evidence. And if you look at sign to Vans
41:04
is oral estrogens are linked to blood clots transdermals or not. But gestrum can
41:07
be done transdermally or orally. But orally crust is the blood brain barrier,
41:13
and it's more soothing to the brain, more anti inflammatory to the brain,
41:15
helps women sleep better. And a testosterone usually done in either as an injection
41:22
or transdermally. Usually women I do transdermally. And the other thing you have
41:25
to remember is that men need all three of those hormones too, just like
41:30
when and DHA and sometimes thy thyroid exactly. Does all have to get balanced,
41:37
right? So yeah, so I always start there when I'm looking at
41:39
what do you need to actually get this down this longevity road, right,
41:44
and then we start working on, you know, getting your nutrition property.
41:46
And that's you know, that's eating a lot more protein than you think you
41:50
need. I so glad, Yeah, I'm so glad you brought that up
41:54
because that was another topic I wanted. It's just the problem we're gonna have
41:59
to have you back on. But um, as long as you mentioned the
42:01
protein. That's another thing that's right now extremely um timely because there's all these
42:09
products or you know, weight loss things that like ozombie yeah that that basically
42:16
you're making you lose muscle or you go on the caloric restriction or the intermittent
42:22
fasting or the or the omad one meal a day, yeah, and all
42:29
those exactly, And so what's going to happen with people? They're gonna lose
42:35
muscle and muscle and bone. Bone is really important. You have to have
42:38
protein. I mean when I look at my elderly patients, um, and
42:43
I have them actually write down their amount of protein their day in a day
42:46
it's something like thirty grams. I mean, we need more protein as the
42:50
age, not less. So you know, I took a good number to
42:53
aim for is one gram per pound of body weight. You know I five
42:57
pounds, I need one hundred thirty five. You know I work out a
42:59
lot. One hundred and fourty grams of protein a day. It's right to
43:01
do. There's no way you can do it in one meal a day.
43:05
And it's one of the reasons I'm not a huge proponent anymore of intermittent fascinating
43:08
because I've seen too many people become protein deficient. I think it can sporadically.
43:14
I think if you're doing it on a regular basis, where every you're
43:16
only eating within a two hour window or three hour window, I think it's
43:20
really hard time not becoming protein deficient. So I think there's some benefits to
43:23
it. Don't get me wrong, but I think it'd be really careful.
43:28
Yeah. Now, I'm a huge fan of a zempic you know, or
43:30
some of glue tide. It's a GP one. It has huge health benefits.
43:35
It actually will help you put on muscle and lose that. If you
43:39
push protein. I can tell you if you've tried the drug. It is
43:43
really hard because you have zero appetite. So that is the biggest problem with
43:46
it. Why people do lose muscle mass and why it's gotten sort of criticized
43:51
by it's because you look at the people just stop eating. They just don't
43:53
want to eat. It's very hard to motivate yourself to eat. Yeah,
43:57
but s an article I was watching podcast actually about a zompic and and they
44:02
said that the one girl who was trying it, she said, you'll be
44:07
burping all the time, you might have some mood changes, you will lose
44:12
muscle. I mean, she went on with all these things, and I
44:14
said, why would anyone want to take that? The GLP one? Uh,
44:17
if that's if you're gonna have all these side effects is for me.
44:21
You know, I don't like to do any drugs. I don't do any
44:22
pharmaceuticals. I mean none, zero, never have I even when they go
44:28
when I go to the dentist and they give you an antibiotic, I stick
44:30
it in my pocket. You know, if they're gonna they don't know that,
44:34
but you know, it's just to me. It's just like I can
44:37
always find an alternative, I hope. But you know for weight loss.
44:40
It seems like this is the name of the game right now that it is.
44:45
I'm going to be the devil's advocate to you on this one because so
44:50
so number one google GLP one agnes and health benefits. The way they got
44:53
discovered was they were they were under discovery for treating dementia and they were very
44:59
very well well, but the people they were treating lost so much weight.
45:02
It wasn't at the ending of these people who weren't eating anyway that it wasn't
45:06
an effective drug. They're still looking at it in terms of using it for
45:09
cognitive decline, so it's still it's back in trials on that. But basically
45:14
the drug company said, oh my gosh, there's a lot more people want
45:15
of those weight don't want to be crazy or be demented, so we'll go
45:19
after the weight loss side. So that's how they got discovered. But if
45:22
you look at their benefits, just you know, I actually said this great
45:24
little picture I show my patience. It shows what GLP one does. So
45:28
it helps form new neurons, it helps cardiac output, it helps it helps
45:32
turn white fat into brown fat, It helps build skills and muscle, It
45:37
increases improves insulin sensitivity. It helps liver functions, great for people who have
45:42
liver fatty liver disease. So it works on almost every organ system because there
45:46
are GLP receptors on all of these organs. So if you look at up
45:52
regulating GLP, it has so many health benefits. I take a low dose
45:55
of it all the time, not for weight loss, but because of its
45:59
benefits or protecting my organs so that my brain I have hittory to mention my
46:05
family from my brain for my heart from my liver. I take a small
46:07
dose all the time, not so much that I get lost appetite. Can
46:12
do it orally or injection injection. And they are coming out with a new
46:15
oral one. There's and there's an oral older form, but they're on the
46:19
new oral one. Now. The people who get the bad GI side effects
46:22
because they can be they can't be bad and sometimes they go away. Usually
46:25
they're worse if you eat badly, so if you eat a lot of carps
46:29
and things like that, so if you're eating a more healthy guy, you
46:30
don't see that as much, but they still can be bad. So they
46:34
now came up with the next generation, which is what it's called tears epetide
46:37
or monjaro in the pharmaceutical world. That's a combination of a gastric intestinal peptide
46:43
with the gluca I'm like peptide and that too together because not cause the side
46:46
effects. So you get the same benefits to the GLP one without getting the
46:51
GI side effects, and it's more effective for weight loss. The downside of
46:55
that drug for me taking it more from my health benefits is that it even
47:00
at a low dose, it makes me move my appetite target me to eat,
47:02
so you don't need to do that. Yeah. So um, So
47:07
basically if the if you look at and then and then I say, okay,
47:12
can you know so a lot of my family has the ftogen, which
47:19
we sort of have fondly named the fat O gene because they have TOG and
47:22
people have the FTO gene have a hard time turning off eating, right.
47:27
They just basically if there's food there, they're going to keep eating it.
47:30
Right. It's just it's there, they're going to keep eating it. So
47:34
that's one of the things that we know. They have a little bit different
47:36
brain chemistry. Well, one of those things that ozempic does is it alters
47:39
the genetic expression of the FTO gene. So here I have a gene that's
47:45
potentially making people have a really horrid time stopping losing weight, and I have
47:50
something that changes that gene. To say I shouldn't use it to me is
47:55
a little bit like, Wow, I could cure your disease, but I'm
47:58
not going to because you should is trying to do other methods. I mean,
48:01
we've got the epigenetic modifications. Now those can stay. Oftentimes after you
48:06
stop the drug. You stop the drug, you'll see people have a much
48:09
better ability to stop eating. Um, it's made an epigenetic change in them,
48:15
and so and so of these drugs. Yeah. So I'm so glad
48:19
that you're where we got on this subject because I didn't plan on talking about
48:22
it. But I know when you brought up protein, I thought, oh,
48:25
this is really timely for But so I think a lot of people would
48:30
be very interested in talking to you about can they do that through Telli Medicine
48:34
if somebody, Yeah, we I'm licensed in forty eight of the fifty states.
48:37
Um, so we have patients actually all over the world. We've got
48:39
patients in Canada and London and Australia. Okay, so we have patients all
48:44
over the world, so you know, I would say a large number of
48:46
our patients are not ours. Sometimes they'll fly in for procedures, but we'll
48:52
look at their X rays and things like that. So yeah, so we're
48:57
very equipped to deal the medicine. It's meant mostly what we do. That's
49:00
great. So tell tell us about skin lack to the collagen and like,
49:05
yeah, I mean, so that's a tough one. And that's where the
49:07
you know, when you look at zempic face, why do people get an
49:09
o zempic face. It's because they lose fat, right, and and what
49:13
really holds our face full as fat? Um. So it's tough because that's
49:17
that whole camera. What what movie stars that years and years ago? Right,
49:22
you can have you know that Marilyn Monroe. You know, if you
49:24
look at people who are a little pudgier, they look younger, I mean
49:29
right, they just have more fat in their face, right, and so
49:34
hence the advocation of fillers and things like that. But then you know,
49:37
it's pretty hard to duplicate what fat looks like on our face. Fat transfers
49:40
have helped that, so can I change the fact that you are losing fat
49:45
a little bit um as as you age, if you're seeing on the thinner
49:49
side. No, and it seems to be preferentially that a lot of people
49:52
as they get older will lose more fat from their face and potentially they're but
49:54
um. So that's a tough one. You either got to carry an extra
49:58
extra way or look a little but sagyear and older. And I think unfortunately
50:01
that's where some of the answers to that are, you know, do you
50:05
have to do things like fat transfers and things. But obviously hormones are going
50:08
to help maintain that a lot more, right so, estrogens, progesterones,
50:12
things like that. For skin laxity, I think we're hitting a whole new
50:16
sort of realm in that. And there's some really good peptides that are helpful
50:20
there. For instance, there's a peptide called GHK copper. G h K
50:24
copper is what helps collagen. It's what makes colligen healthy in our body.
50:28
So you can keep yourself injections of it to sort of help all over.
50:31
But you can also use a GHK copper skin cream. And it's that with
50:36
things like are jurlin and luphasal, which act like botox a little bit in
50:39
your skin. So those peptides that have a botox like effect, so sort
50:44
of the spine lines, you know, the fine lines gone, and you're
50:49
JJK copper and naturally made by our body. So I like peptides that are
50:51
naturally made by our body, right, so they're not something foreign to us.
50:54
So that's how our body repairs collagen is with GHK copper. So so
50:59
that's great, you know. And then I think the one of the things
51:02
we use a lot of is you might be familiar with rapid mice and or
51:06
cyrilemas and the rap mycen's gotten a lot of play in the longevity world because
51:10
it blocks. It's called emptor. And when emptor is accelerated firstands from a
51:16
million target of rapid micin, Hans rapid license sits in emptor turns it down
51:22
and that slows AG. So almost every long gevity doc is gotten on board
51:28
with rap mice. It appears, we don't know for sure, but it
51:30
appears to be a really good way to delay AG. Well. You can
51:34
do rapid mic in topically as well, because it really works in skin cells
51:37
as well to help kill off all the senescent dead cells. So so if
51:42
I use like a combination of VHK copper skin cream and rapid mice and skin
51:45
cream, I can do a lot for helping people's skin or collagen integrity.
51:51
But the JHK copper is probably the best for collagen integrity. And then the
51:54
ciri lima skin creams to kind of get rid of the older cells so we
51:58
can regenerate newer, healthier cells. You actually supply that to patients, Yeah,
52:02
we have compounding pharmacies make it for us. Yeah, yeah, the
52:05
true the combo. Yeah, oh that's incredible. Okay, I didn't you
52:08
even know about that? And then okay, so let's move on to peptides
52:13
that since we touched on it and I don't want to run, let me
52:15
just look at my Okay, we have like we have like four minutes,
52:20
so give us your quick primer on the Okay, you touched on BP one
52:24
thirty seven, you touched on the copper. What about the twelve ninety five
52:30
DJC and morale so um so so again one of my sort of when I
52:38
talk about aging, one of the things I always say is repair what we
52:42
lose or replace what we lose, right, So we lose with thyroid,
52:46
lose progestrum, We lose peptides as well. Yeah right, people think of
52:52
peptides like a pharmaceutical or something. We don't have it. We make peptides,
52:54
right, We make BPC, peptides, we make instantly. Growth factor
53:00
are all peptides that our body naturally makes, just like insulin exactly. So
53:05
basically I'm a big advocate of replacing at least those peptides periodically. So with
53:10
my long deamity patients, we will put this sort of series of peptides as
53:15
Sometimes I'll use like BPC with thimus and beta four to repair an injury,
53:19
but lots sometimes I'll just cycle people on and off of those through time.
53:23
As I age, I will make less of them. So if I want
53:25
to replace what I had when I was young, the inde So those include
53:30
things like the thymic peptides. Yeah, babies, we have a giant thymus
53:34
gland in our chest. Yeah, but it took our immune system. It's
53:37
you know, and but by time you're you know, my age, it's
53:40
a calcified little nub and right, so basically I got to get back with
53:45
the thymus gland makes seems like thimulant that would be one of your bioregulators,
53:49
or thimus and alpha one or thimus and beta four are sort of more distinct
53:52
forms of that BPC, which is made by our gut to help us repair
53:57
tissue, help our brain improves, b d n F improves. But so
54:00
basically you can do BPC either's a subcutasous injection or orally or must go skeletal
54:07
as injection and orally forget right then and then I've got I'm gonna I'm gonna
54:12
decline in growth hormone as I age. But even if you're doing everything right,
54:15
exercise and everything, you're going to decline in growth hormone. So better
54:21
than giving growth hormones. So probably giving growth hormones, it's very very horrid
54:23
to dose it. So you don't have these very high surges high surge growth
54:28
hormone and get these very high levels of IGF. That's probably not good for
54:32
you. It's probably pro and so we use I want to call bioregulator peptides,
54:37
which are are c JC and epimrellon are basically they're going to encourage your
54:45
own pituitary gland to make and release more of the growth hormone, so my
54:52
own body to release more growth hormone, increase IGF levels. So cjc ipamrellon
54:58
Usually how people do those pretty continuous six out of seven days of the week.
55:00
They do a little injection before they go to bed at night. Helpsless
55:02
sleep, helpless recovery, really great for not sleeping well, you know,
55:07
getting growth home levels up at night is really helpful there, you know.
55:09
So so those are kind of base ones that we use in almost everybody.
55:15
And then we talked about mitochondrial dysfunction um I cycle A lot of my clients
55:20
on what's called mitochondrial peptide. It's called sc so or mitochondria make peptides too.
55:25
MODESTC tells your body to make new mitochondria. It's it's in pharmaceutical trials
55:31
as an exercise by medic so it actually acts like exercise. So people who
55:37
can't exercise, you know, they're too debilitated or they've been they're laid up
55:39
in bed, you can actually give them modest C and it acts to their
55:43
body like they're exercising, So you get by mitochondri biogenesis, healthier mitochondria.
55:47
So basically you can use that cycle people on and off and that to kind
55:51
of replenish some of that mitochondrial function. So those are kind of the go
55:54
tos. And there's you know, there's two different peptides we use. I
55:58
know it gets confusing, but those are the basic ones and I yeah,
56:00
those are basic ones. BPC the thymic peptides, right home peptides CJC and
56:06
epomrellan, and then I the mitochondrial peptide. So before we go, I
56:12
just I know you wanted to talk to us about a little gift for our
56:16
viewers, and could you just take a moment and just tell us what that
56:20
would be, because I think it's so generous of you, and I just
56:22
want everybody to know. So, Guy's one of the things we've done is
56:27
because we realize that that people are so like people like you, Michelle,
56:30
appreciate that you're dating out there and spraining this world. So people learn it
56:32
because you can't learn this stuff from your doctor, right and if you talk
56:36
to your doctor about it, usually they'll just ignore you. And there's a
56:38
few doctors who are good at it, but you know, not a lot.
56:40
So what we decided is well put together a course that really help people
56:45
understand. So we've you know, we have a peptide course and a hormone
56:47
course, and so if you if if you join what's called our Human Optimization
56:52
Academy. It's an academy that's designed to kind of turn you into a doctor
56:54
in a sense, you know you still doctor, but basically make you understand
57:00
Dan this stuff. It's all taught from scientific knowledge, you know, basically
57:02
literature only it's none of my opinions. It's literature. So teaching you the
57:07
pure reviewed literature so you can make logical decisions. So you can learn this
57:12
stuff. And and you know, there's courses on everything you want to know.
57:15
There's orthopedics, how do we deal with peck injuries? What if you
57:16
have an ACL tear? And then we do these monthly q and as which
57:20
are really fun because honestly, this group is so smart and they ask the
57:22
best questions. They keep me on my toes. There's a lot of physicians
57:25
in the group now too, So by joining that, you guys can actually
57:30
really learn this stuff, at least to a degree where you can talk about
57:34
it and understand it. Because you're going to have to take charge of your
57:37
own health. I don't think you can rely on from us to it and
57:40
make better choices because you take their choices right there. And so if you
57:45
go to Human Optimization or be Ali Academy, so be Ali dot Academy.
57:52
Okay, you put the code angels ten in there, they'll get ten percent
57:55
discount in membership. It's not a super expensive membership. We've try to keep
57:59
it so it's very you know, doable for people, so we can start
58:01
spreading this word and having people learn this stuff and not you know, I
58:06
think the problem with learning from Instagram influencers is they're being paid to say what
58:10
they say a lot of times, and people need to start learning from scientific
58:14
data, right, perfect, Okay, well we have to end. Sadly.
58:20
I could talk to you for another hour easily and still not run out
58:23
of things to say. So, doctor Years, I just want to say
58:29
you are a truly amazing doctor one because you combined your two specialties into something
58:36
that's it's like a gestal. You know that the sum is greater than the
58:40
I mean, the whole is greater than the sum of the parts. So
58:44
thank you so much for doing that. A lot of people go around with
58:46
injuries that don't know how to heal them. And yeah, please, you
58:51
guys have knee pain, joint pain. You're like facing and y'all they told
58:53
you all you can do as your place. They need police, call us
58:57
much more. That's thank you.