261-Spatial Atlas of Brain Development and Neuroinflammation

Paper Talk · Nov 24, 2025 · 15m

This research using spatial multi-omic technologies, such as deterministic barcoding in tissue (DBiT)-based spatial tri-omics (spatial ARP-seq and spatial CTRP-seq) and CODEX multiplexed imaging, to investigate the spatial dynamics of brain development and neuroinflammation. The study profiles the epigenome, transcriptome, and proteome simultaneously in mouse brains across various postnatal developmental stages and in a focal demyelination mouse model induced by lysolecithin (LPC), benchmarking findings against human brain development samples. Key results include the spatiotemporal regulation…