331-Architecture of the Neutrophil Compartment

Paper Talk · Dec 22, 2025 · 18m

This research introduces NeuMap, a comprehensive transcriptional and functional map of the neutrophil compartment developed using single-cell RNA sequencing of mouse and human neutrophils across various tissues and pathological conditions. The study identifies a conserved and finite set of seven distinct transcriptional hubs (e.g., PreNeu, Immuno-silent, IFN-response, and Immunosuppression I/II) that define different functional states of neutrophils. Furthermore, the authors utilize RNA velocity and genetic tracing to map the transcriptional trajectories and dynamics of neutrophils as they…