353-IL-36γ Armored CAR T Cells Reprogram Neutrophils
The research article describes a breakthrough in solid tumor immunotherapy using IL-36γ armored CAR T cells. While traditional CAR T therapies often struggle with antigen heterogeneity and the immunosuppressive tumor microenvironment, this study demonstrates that secreting the pro-inflammatory cytokine IL-36γ allows CAR T cells to effectively eradicate tumors. The primary mechanism involves reprogramming neutrophils into a specialized subset that possesses both tumoricidal activity and antigen-presenting capabilities. These "educated" neutrophils activate the host's own immune system…
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