401-Epigenetic Plasticity in Germinal Centre B Cells
This research identifies a unique plasticity state in germinal center B cells that is temporarily triggered by T follicular helper (TFH) cells. Under normal conditions, these B cells undergo extensive epigenetic remodeling to adapt their function, yet they remain susceptible to malignant transformation. The study demonstrates that this flexible state, while necessary for a healthy immune response, can be hijacked by lymphoma mutations to promote aggressive disease. Specifically, the loss of histone H1 or mutations in BTG1 allow B cells to bypass standard developmental barriers, adopting…
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