655-Spatial Atlas of the Human Suprachiasmatic Nucleus

Paper Talk · Mar 17, 2026 · 18m

This research presents a spatial and single-cell transcriptomic atlas of the adult human suprachiasmatic nucleus (SCN), the brain's primary circadian pacemaker. By utilizing advanced imaging and sequencing, researchers identified seven distinct neuron subtypes with unique genetic signatures and spatial arrangements within this small hypothalamic region. A cross-species comparison with rodents and non-human primates reveals a conserved regulatory axis involving the genes LHX1 and RORB that organizes SCN function. The data highlights that while core clock mechanisms are preserved, the human SCN…