677-TabulaTIME: Pan-Cancer Landscape of Profibrotic Ecotypes
The paper introduces TabulaTIME, a massive pan-cancer single-cell resource that integrates data from over four million cells across 36 different cancer types. By utilizing advanced computational frameworks, the researchers identified a specific group of CTHRC1+ cancer-associated fibroblasts that reside at the boundary between healthy and malignant tissue. These cells appear to create a physical barrier that prevents immune cells from infiltrating the tumor. The study also highlights a profibrotic ecotype formed by the interaction of these fibroblasts with SLPI+ macrophages, which contributes…
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