Metformin for Vision Longevity? The Mitochondria–Oxidative Stress Link in AMD (Systematic Review)
This Deep Dive breaks down a 2015 – late 2025 systematic review asking a modern longevity question: could metformin — best known as a first-line type 2 diabetes drug — help preserve vision by protecting mitochondrial function in age-related macular degeneration (AMD)? The episode frames AMD as a cellular stress + mitochondrial dysfunction + oxidative overload problem centered on the metabolically intense retinal pigment epithelium (RPE). You’ll hear the review’s three main takeaways: (1) metformin often reduces ROS and inflammatory signaling in RPE models, (2) it may preserve mitochondrial…
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