1587-Hijacking Exocytosis for Metabolic Reprogramming
The paper details the development of a dual-compartment lipid carrier system designed to overcome the immunosuppressive effects of lactate in solid tumors. By engineering natural killer (NK) cells to carry nicotinamide mononucleotide (NMN) and dichloroacetate (DCA), researchers successfully restored intracellular NAD+ levels and depleted extracellular lactate. This innovative approach "hijacks" the ER-Golgi secretory pathway, allowing for the precise, localized release of therapeutic payloads at the tumor site. Experimental results in osteosarcoma models and patient-derived xenografts…
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