905-The Core Neural Signature of Psychedelic Drug Action

Paper Talk · May 5, 2026 · 15m

This mega-analysis published in Nature Medicine integrates eleven neuroimaging datasets to establish a definitive map of how psychedelic drugs restructure human brain communication. By analyzing five substances—psilocybin, LSD, DMT, mescaline, and ayahuasca—the researchers identified a universal signature of increased connectivity between high-level thinking areas and basic sensory networks. Conversely, the study found that internal communication within individual networks often weakens, though these effects vary more significantly across different substances. The team utilized Bayesian…