1604-Reprogramming of Alveolar Macrophages for Immunotherapy

Paper Talk · Sep 23, 2026 · 19m

This research describes a novel immunotherapy strategy that uses liposomal nanomedicine to genetically reprogram alveolar macrophages directly inside the lungs to fight cancer. By administering a specialized nanoparticle via intrapulmonary nebulization, the scientists converted these local immune cells into chimeric antigen receptor (CAR) effectors without the need for complex external laboratory manipulation. These engineered CAR-AMs effectively target and destroy lung cancer cells while simultaneously shifting the tumor environment from an immunosuppressive state to a pro-inflammatory one…