197-How Bacteria Modifies Cancer Cell Architecture
This article investigates the mechanism by which tumor-infiltrating bacteria, specifically Fusobacterium nucleatum (F. nucleatum), influence cancer progression within the tumor microenvironment (TME). The research, which employs spatial imaging, single-cell transcriptomics, and in vitro/in vivo models, challenges previous paradigms by demonstrating that high loads of extracellular bacteria disrupt cancer epithelial cell-to-cell contacts. This disruption leads to a quiescent state or G0-G1 cell-cycle arrest in the epithelial cells, resulting in reduced proliferation and a scattered cell…
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