563-Intracellular Bacteria Promote Breast Cancer Metastasis
This research explores how intracellular bacteria residing within breast cancer cells drive metastatic recurrence by manipulating the host's immune system. The study identifies that when bacteria like Staphylococcus xylosus invade tumor cells, they activate the cGAS-STING signaling pathway, which subsequently triggers the expression of IL-17B. This molecular shift recruits and reprograms neutrophils into an immunosuppressive state, allowing cancer cells to evade immune surveillance and colonize distant organs like the lungs. In contrast, extracellular bacteria were found to promote an…
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