Latest / Pediatrics Now: Cases Updates and Discussions for the Busy Pediatric Practitioner / Pertussis Outbreak Plus: Preparing for a Tough Flu Season
Transcript
- 0:00I'm Holly Wehmint, and this is Pediatrics Now.
- 0:03Click on the link in the podcast for free credit that may include CME,
- 0:08MOC, or ethics credit, depending on our topic or podcast.
- 0:12Our talk by the Chief Medical Officer at Microsoft is going to run next week
- 0:17because we're focusing today and this week on a more breaking story, the flu and pertussis.
- 0:24And joining me here in the podcast studio is Dr.
- 0:28Dina Sutter. She is our pediatric infectious disease doctor at University Health
- 0:33and UT Health San Antonio.
- 0:35Dina, thank you so much for being here in the podcast studio.
- 0:38Thanks, Holly. Appreciate it. So just in time for Thanksgiving,
- 0:42we're getting these warnings.
- 0:44There's, for example, there's a story out today on Texas Public Radio that reads,
- 0:50When most Americans think about 1968, their minds turn to the twin tragedies
- 0:54of the assassination of Martin Luther King Jr. and Robert F. Kennedy.
- 0:57They may think of the escalation of the Vietnam War or anti-war protests.
- 1:03Few recall that it was the year that H3N2 variant of the influenza virus emerged
- 1:08in Asia and began a steady march around the globe and resulting in a pandemic,
- 1:14killing between 1 million and 4 million people.
- 1:18And this is the strain of the flu that is strong this year. This sounds so dire.
- 1:25Yeah, I love TPR, but that's a little melodramatic. A way to get people's attention, I suppose.
- 1:32So basically, you know, to sum it up, and the rest of the article goes into
- 1:35this, that, you know, the H3N2, H1N1 and H3N2 kind of trade off year to year,
- 1:42not back and forth, you know, directly.
- 1:44But we typically have heavy H1N1 strains, infections.
- 1:52We do know that H3N2 infections, when we have those prevalent in years,
- 1:56they tend to be overall more severe than H1N1 infections.
- 2:01So the the they called it the Hong Kong flu is what they called it in that time period that that's,
- 2:11that was one of our pandemics. And this year, this is not considered pandemic.
- 2:16It's going to be considered an epidemic.
- 2:18So that intro was a little bit misleading in terms of what's going to happen.
- 2:24We do have years where H3N2 is prevalent and causes most of the infections.
- 2:29This year, we do have some drift as opposed to a shift.
- 2:33And so the subclade K, which they were referring to in this article,
- 2:38is slightly different, actually has several different mutations,
- 2:42but is a little different than what they anticipated and put in the vaccine this year.
- 2:48So there were some mutations from the southern hemisphere H3N2 that happened
- 2:53towards the end of their yearly epidemic.
- 2:56And so there's a little bit of mismatch in the vaccine. So far,
- 3:01we've seen in, not so much in the U.S., but in Asia and in...
- 3:08The UK, there has been a very early influenza season, and they have seen this
- 3:15H3N2 subclane K be the predominant flu type that's circulating right now.
- 3:22So the concern is because of an early season and because of a mismatch,
- 3:27and there's more severe influenza in those areas,
- 3:30even though it's not an actual shift versus a drift, which classically causes
- 3:36these pandemics, we may have a more severe year.
- 3:38And so far this year, we do know that flu cases are ticking up a little bit
- 3:42faster in the U.S., not as fast as in those other countries,
- 3:46but a little earlier than we typically expect.
- 3:49So we're kind of on the brink here.
- 3:52So what's your advice to pediatricians and to us all?
- 3:57I think really talking to families about the importance of an influenza vaccine,
- 4:03which I know pediatricians are already doing.
- 4:05I mean, this is kind of like, you know, standard fare, but really emphasizing
- 4:09the fact that this vaccine is still probably very effective in terms of influenza vaccines.
- 4:16The mismatch is not, at this point, with the data we have, felt to be such a
- 4:20mismatch that it's not going to work.
- 4:22Sometimes families, when they hear about this on the news, they'll get a little
- 4:25bit discouraged and they'll say, well, what's the point of getting the vaccine.
- 4:28But overall, I think that there are a lot of families out there that either
- 4:33have mistrust in vaccines in general, or they just feel like the flu vaccine
- 4:39isn't necessary for them, and then by extension, their children.
- 4:42And the most important influence that they can get, you know,
- 4:47besides, you know, hearing maybe misinformation from the other parents,
- 4:51that type of thing, or family members, is their pediatrician.
- 4:53And if they are bringing a child to the pediatrician, they tend to,
- 4:57that's like the strongest influence on them, really.
- 5:00And I think the pediatricians out there are very familiar with this and they know it. So bottom line.
- 5:06Bottom line, Dina, what is the data showing right now regarding the efficacy
- 5:10of the flu vaccine this year for kids and also adults?
- 5:16So since we're kind of on the cusp of the major part of the flu epidemic this
- 5:22year in the U.S., we don't have a ton of data from the U.S.
- 5:25And I don't see anything nationally gathered so far in terms of vaccine efficacy, but effectiveness.
- 5:32But in a study in the UK at the beginning of the season where they had a large
- 5:38number of cases coming into the ED, they compared two cohorts.
- 5:42And between adults and children, the vaccine effectiveness appeared to be about the same,
- 5:48which they quoted 72 to 75 percent effective at influenza related emergency
- 5:54department attendances and hospital admissions in pediatric patients.
- 5:59That was lower in adults, but the reference was, you know, the baseline effectiveness,
- 6:05and they felt that this was not very different than the norm,
- 6:08despite those mutations in the H3N2.
- 6:13So, as we're heading into, you know,
- 6:16we're recording this the day before Thanksgiving, and I'm sure that pediatricians
- 6:22will be getting questions from patients and families leading into the holidays
- 6:27and holiday gatherings.
- 6:30What is your advice there for babies who are too young to be vaccinated?
- 6:36For the flu or children who are maybe more susceptible to complications from the flu?
- 6:43I think most pediatricians would give the same advice in terms of hand-washing,
- 6:48in terms of trying to keep the child away from sick people and don't let a family
- 6:52member hold your child without hand-washing.
- 6:55Anybody who's sick should be wearing a mask.
- 6:58The hope would be that post-COVID people would be wearing a mask.
- 7:01People are a little more receptive, at least most people are a little more receptive to wearing a mask.
- 7:06It's less of a social stigma. And I think it's very appropriate if you can't
- 7:09keep sick family members from attending a gathering.
- 7:12And Dr. Jason Bolling, our colleague in infectious disease,
- 7:16adult infectious disease, he was mentioned in an article saying a baby who's
- 7:21not vaccinated or a baby who's too young to be vaccinated should not be around
- 7:25friends or family who are not vaccinated for the flu.
- 7:28I was thinking like for my family tomorrow, that's not realistic.
- 7:31I know everyone's not. I mean, in a perfect world, that's true.
- 7:34I definitely would feel uncomfortable, especially if we were a little further
- 7:39into our annual epidemic.
- 7:40But there are certainly flu cases. The numbers are increasing very rapidly.
- 7:44So I know that there are families that have been very strict about all family
- 7:49members must be vaccinated against things like pertussis and influenza.
- 7:54I don't think that depending on when you're in a large gathering,
- 7:58I think you just have to use common sense and try to mitigate the risk a little
- 8:02bit by keeping, you know, sick people away from the child.
- 8:05And, you know, everybody has the sort of their own willingness to to take a
- 8:10risk. But I think really the role of the pediatrician is to emphasize trying
- 8:15to reduce those risks and talking about it in a common sense way.
- 8:18And a lot of us have families where, like in my big family, we know that family
- 8:23members are more likely to bring their kids while they're sick or show up to
- 8:26family events while they're sick. So it gets complicated with family gatherings.
- 8:31Yeah, I mean, kids are sick. Kids in daycare are sick. Kids in school are sick.
- 8:34And we have many, many different viral infections going on based on,
- 8:39you know, my experience in the hospital in the last couple of weeks. I can name many viruses.
- 8:44So it isn't just influenza for sure.
- 8:47And I think, you know, I think that really trying to talk to family members
- 8:51in a common sense way in terms of, you know, your kid is sick.
- 8:55Please, you know, don't let them be near my baby, et cetera.
- 8:58But, you know, otherwise it's a little difficult. Mm-hmm.
- 9:03So regarding the flu, have you seen very many cases of the flu in the hospital?
- 9:09I have not, which is great. I think I'm about to see a whole lot.
- 9:13There have been certainly some adult cases, and I've seen a few pediatric cases here and there.
- 9:19But I think given the risk of a more severe influenza season based on the information
- 9:26we have from other countries and from, you know, preliminary information from the U.S.
- 9:31We have a very complex population at university, and so the patients who have
- 9:39influenza, certainly, you know, healthy children in the community hospitals
- 9:42who could get sick, and I'm expecting to have a lot of complications this year.
- 9:47When should clinicians initiate antivirals at any lower thresholds this year?
- 9:54I think that remains to be seen. I certainly think that the definition of a
- 9:59high-risk patient could be somewhat interpreted based on, you know,
- 10:04a child with mild asthma.
- 10:05I think I would definitely, if there was not a contraindication, treat.
- 10:11And other chronic illnesses, which may not be listed in the list, the classic list.
- 10:17I think everybody needs to go and identify your high-risk population.
- 10:22Make sure your staff really knows what a high-risk population is.
- 10:26Maybe even posting a list of those high-risk conditions where the parents can
- 10:31read them so that they can understand that if their child is high risk.
- 10:35Not that the pediatrician wouldn't identify that, but making sure that they
- 10:39really know that if their child is diagnosed with flu, that they should be asking
- 10:43for antiviral medication.
- 10:44So you're really getting the parent involved in the decision-making process. That's a great idea.
- 10:50How are you advising clinicians about simultaneous testing for flu,
- 10:55RSV, COVID versus targeted testing?
- 10:59That's like, I don't know that, I don't really know how to answer that because
- 11:03each practice has their own,
- 11:05you know, whether they send the patient to the lab and order tests,
- 11:08whether they have their own PCR tests that they're running in their practice, point of care testing.
- 11:15I think that if you, you know, many places are just doing respiratory PCRs with
- 11:21the whole panel, which sometimes gives us more information than we really want
- 11:24and, you know, increases the expense depending on how the patient's insured.
- 11:28I think really it's up to the clinician to understand and to be on,
- 11:33you know, to be aware of what is circulating at that time.
- 11:35And then what can you treat? I mean, you know, RSV in a young infant,
- 11:41you know, you do need to know about it, but it's not treatable.
- 11:44COVID in most cases you're not going to be treating and the severe COVID cases
- 11:48have, you know, not been a huge problem lately.
- 11:51And if that worsened, then you should be testing for it. I think for influenza,
- 11:58knowing that these numbers are going up, I think you should have a very low
- 12:00threshold to test for it.
- 12:02When you get these respiratory PCRs, and sometimes the kid's got three viruses,
- 12:06right now I'm seeing a lot of them that are not treatable.
- 12:09It's more just for infection control and awareness in the hospital.
- 12:13But I would also like to warn against one thing that's not really the question you asked me.
- 12:18I have seen patients come in, and I don't know how many practices in San Antonio are doing this,
- 12:23but I have seen practices in San Antonio who have respiratory PCRs that include
- 12:28bacterial targets other than things like the atypicals like Bordetella pertussis and mycoplasma.
- 12:35So they're including classic typical bacteria like Streptococcus pneumoniae,
- 12:40Haemophilus influenzae, which are colonizing bacteria.
- 12:43And really, those tests are not useful. I don't like,
- 12:50seeing them because there's a lot of people who misinterpret them when a child
- 12:54is supposed to be colonized with these bacteria.
- 12:56And then I think the practices are getting kind of sold sometimes on these panels,
- 13:01which I think are inappropriate.
- 13:02And I actually had a patient in the hospital the other day that the mother came
- 13:05up after she got the results faxed and said, oh, there's this bacteria and this bacteria.
- 13:09And I said, yeah, we don't know.
- 13:12We don't care about that, really. That doesn't really represent what's going on in the child.
- 13:15It doesn't prove that the child's got you know, pneumococcal pneumonia.
- 13:19So if you have a panel like that, or you're seeing people come in with panels
- 13:23like that, really try to educate people and understand what that means.
- 13:29Okay, that's also great advice.
- 13:32Should we real fast, before we move on to pertussis, go through warning signs
- 13:37that this looks like it could, just a refresher, that this could be the flu,
- 13:41that it's a good idea to test for the flu?
- 13:43And then when is it red flags, this child in front of me should go,
- 13:48they should go to the emergency room?
- 13:50I think, you know, during flu season, a kid with a respiratory illness and high
- 13:55fever absolutely should be tested.
- 13:57I think flu testing tends to be very reflexive when there's a lot of flu circulating,
- 14:03and so a lot of people would test kids who are much less ill.
- 14:08I don't know that you need to be testing every child who comes in with a cold
- 14:11during flu season, but if they're exposed, which they probably were if there's
- 14:15a lot of circulating flu, whether it's at home or at school,
- 14:18I think it's appropriate to test them.
- 14:20So depending on your resources, you may want going to conserve them,
- 14:24but I think in most cases really just the reaction should be,
- 14:27you know, the child who is ill with severe,
- 14:30with high fever looks ill in particular, and then otherwise people are just
- 14:35kind of testing everybody during flu season if they come in with any kind of
- 14:38compatible presentation.
- 14:40In terms of sending a child to the hospital, I think most pediatricians are
- 14:44pretty comfortable with saying, you know, respiratory distress, hypoxemia.
- 14:49You know, signs of a secondary bacterial infection that might be more severe
- 14:54or a child who's at high risk.
- 14:56So your patients who have severe chronic medical problems, they may need to
- 15:00be assessed in the emergency department if you don't have the capability to do all the workup.
- 15:04And I think most pediatricians do a pretty good job of ascertaining who those patients are.
- 15:11Dina, before we move on to pertussis, anything else you want to say about the flu?
- 15:17I think, like you said, I think I would be comfortable with treating more patients
- 15:22as long as we don't have any shortages of drugs.
- 15:24We know we can treat, you know, any age with oseltamivir.
- 15:29And so I think that if we are able to mitigate some of these problems by treating
- 15:34kids, you know, I'm not advocating treating every child, but really be aware
- 15:39of those who are at higher risk.
- 15:41And then, you know, just continue to try to have those conversations about the
- 15:47importance of influenza vaccine.
- 15:49Just, I'd love to tell, you know, anecdote is always really powerful.
- 15:52And so like anecdotally,
- 15:53I mean, I have talked to several parents who are quite educated,
- 15:57working in healthcare, and just casually mentioned that they never get influenza
- 16:01vaccines when I'm seeing their chronically ill child.
- 16:04And it's just sort of baffling to me that people cannot understand that although
- 16:10it's certainly not 100% effective and we have to get them every year.
- 16:14It's really important because we do have, you know, we had almost 300 pediatric
- 16:18deaths from influenza in the United States last year and anticipating a higher number this year.
- 16:23And so, you know, some of those children were not chronically ill kids and almost
- 16:27all of them were unvaccinated.
- 16:29So why not do everything you can? Exactly. Yeah, for sure.
- 16:35And I think a lot of people don't realize that, that a child,
- 16:38a healthy child could, an otherwise healthy child, could die from the flu. And they do every year.
- 16:43There's kids who do. I have seen several, and it's absolutely devastating.
- 16:47I volunteer in the NICU at the Women's and Children's Hospital,
- 16:50and it was nice where there was a deadline.
- 16:51You absolutely have to get your flu vaccine by this date, you know,
- 16:55and it's nice to have that.
- 16:56But most, a lot of people don't have that reminder.
- 16:59Yeah, the NICU is extremely strict about things. You know, they really do a
- 17:03great job of protecting their babies.
- 17:05And, you know, but I don't, you know, I don't feel that like,
- 17:09you know, other environments are as strict.
- 17:12They don't tend to be as strict. And so really talking to the parents and really
- 17:16talking to the health care workers as well and just making sure people are passing,
- 17:20not passing on misinformation. information.
- 17:22And I was talking at a family dinner with extended family, and I quoted Dr.
- 17:27J.B. Canty, also in Pediatric Infectious Disease here, where he was saying,
- 17:31like, every time we get our flu vaccine, we're adding to our lifetime immunity for the flu.
- 17:37Absolutely. Which I think a lot of people don't realize. It's amazing.
- 17:40Yeah, it's important. You can say, oh, well, you want to get natural influenza.
- 17:45Well, that really stinks to get it. It does boost your immunity. But.
- 17:50And one of the examples is when we had the influenza pandemic in 2009,
- 17:592010, I'm trying to remember the year, 2009, we thought we were going to have
- 18:04a lot of elderly people die.
- 18:06And actually, they actually had leftover immunity from having influenza, you know, decades ago.
- 18:13But every time you get another dose of vaccine and the vaccine's different every
- 18:17year, it It adds to your immunity, which is kind of like armamentarium,
- 18:22you know, against various types of influenza.
- 18:25So people who have been vaccinated every year and, you know,
- 18:28the people, unfortunately, people who have had natural disease,
- 18:31you know, but they are they're fairly well protected against new new variants.
- 18:37Shall we move on to the pertussis outbreak in San Antonio?
- 18:41Sure. Go ahead. And so we have, and our listeners, our pediatric practitioner
- 18:46listeners are also throughout the United States and the world,
- 18:50not just here in San Antonio, but worldwide.
- 18:52We are having an outbreak, apparently, here in San Antonio.
- 18:56One pediatrician was telling me that a patient, their baby, was having some
- 19:02difficulty breathing, and luckily they took the baby to an emergency room,
- 19:07and there was the panel test.
- 19:09The family went home with the baby, and then someone from the emergency room
- 19:14called and said, come back because it's pertussis. and they were shocked because
- 19:18there weren't really, there was no whooping with the cough, which apparently babies don't. Yeah.
- 19:24Yeah. I think, I mean, young infants really don't have the classic whoop.
- 19:28It's usually more of an, you know, older infant or toddler type of,
- 19:31or, you know, preschooler presentation.
- 19:34So it's harder to identify in a young infant for sure, but it's also hard to
- 19:39identify in anybody in the first phase of pertussis, you know.
- 19:43Because it seems like a cold? It seems like a cold.
- 19:46So the catarrhal phase is the first, you know, one or two weeks after an incubation
- 19:49period of maybe, you know, maybe a week to two weeks. You know, it's kind of variable.
- 19:55So, you know, you may not even know where the child acquired it,
- 19:59you know, if they were in school, around other kids, traveling, something like that.
- 20:03So in the early phase, it really just looks like a cold typically.
- 20:07They might have like a, you know, they'll typically have a runny nose,
- 20:11some sore throat, maybe a low-grade fever, you know, malaise, that type of thing.
- 20:16And then young infants, you know, towards the end of that phase is when they're
- 20:20at risk to develop apnea.
- 20:22And I've certainly seen young infants who had pertussis who looked,
- 20:27they looked different than infants who had RSV. You know, they just, they looked...
- 20:33A little bit more ill in some cases, but I also noticed when they got to that
- 20:36next phase, the pyroxysmal phase, they were coughing in a way that I don't see
- 20:41young neonates typically cough.
- 20:43They don't necessarily have that associated whoop because they don't have the inspiratory muscles.
- 20:49Their airway is not built to create that sound. Even if they breathe in very
- 20:53violently, they still wouldn't do that. But apnea is a big feature.
- 20:57And so any child, young child with respiratory distress or looking ill, you should spec this.
- 21:03The other classic feature that if you got labs is significant leukocytosis,
- 21:09specifically lymphocytosis, tends to occur in infants as opposed to older kids.
- 21:15And that can occur during the initial, the catarrhal phase before,
- 21:20you know, the later stages.
- 21:22And so that could be a clue if you have a kid who, let's say,
- 21:25is in the emergency department or the urgent care and you get labs and you see
- 21:29a very high lymphocyte count, if you weren't already testing that kid with the
- 21:32respiratory panel, then I think I might be doing that.
- 21:36What about in older kids with pertussis? We would hear that classic whoop?
- 21:41Yeah, I mean, you don't always get that, but if you hear that,
- 21:44those are, you know, the severe cases. Those kids are miserable.
- 21:48You know, these kids are coughing, coughing, coughing, coughing, gasping for air.
- 21:51They can have associated complications just from the severity of the cough.
- 21:56You know, they can, rib fractures have been described and subconjunctival hemorrhages
- 22:01and other sequelae because they're just coughing so violently.
- 22:06So if the whoop is like, you know, kind of the icing on the cake,
- 22:11like you might, you know, you might get it, you might not get it.
- 22:13And so you should still have a clinical suspicion when there's an outbreak that
- 22:16going on like there is right now, even if you don't hear it.
- 22:19And with the outbreak, I mean, would you recommend doing that panel test for
- 22:23any baby that has cold-like symptoms?
- 22:27I don't, you know, I think it's, I really want to defer to the pediatrician's
- 22:31judgment here as long as they know what's circulating.
- 22:35So, you know, some practices tend to do a lot more tests than others.
- 22:39If the child is, especially if the child's mother was unvaccinated during pregnancy,
- 22:45you know, if you have a young infant, if the family is unvaccinated,
- 22:48if they're around unvaccinated people,
- 22:50then the risk of the child having pertussis, especially if you knew they were
- 22:53exposed, is higher overall.
- 22:55So you need to kind of use that, you know, calculate that out and say,
- 22:58you know, if you have a child with a mild runny nose and the parent brings them
- 23:01in for whatever reason, I'm not sure I would test it for every single child.
- 23:04But if you thought there was a possibility they were exposed and they were,
- 23:07especially if the family is unvaccinated, you know, and they're around other
- 23:10unvaccinated people, that's what I would say.
- 23:13Okay, you know, we have an outbreak going on. The child has a runny nose.
- 23:16You know, what's your level of suspicion? And so, but I would really defer to
- 23:21the pediatrician's judgment.
- 23:23You know, if the child looks ill, they're probably going to the emergency room
- 23:26anyway, and they are going to get tested.
- 23:28But when it comes to a baby with pertussis, the baby could seem like she has
- 23:33a cold and then just stop breathing?
- 23:35It can happen. I mean, that can also happen with things like RSV as well.
- 23:39Apnea is a significant concern, and we tend to hospitalize those children to
- 23:43have them monitored and watched closely if we know they have pertussis.
- 23:47So the problem is, as you said, if the child just has like mild symptoms initially
- 23:52and then develops apnea out of nowhere, it's really hard to predict.
- 23:56And so, you know, I think really the pediatrician identifying cases where the
- 24:03child is at increased risk for protestis during an outbreak and testing them
- 24:06is the best prevention for this case,
- 24:10is that the child either should be treated and possibly observed in the hospital.
- 24:15It's not, we've only had, I was going to say only, we had about 10 infant deaths
- 24:21in the United States that were reported associated with protestis.
- 24:24We've had- So far this year? Last year, in 2024.
- 24:27And so this year we've had, I don't know what the number is exactly.
- 24:31I know at least seven of at least seven, mostly in southern states.
- 24:35And so overall, there are not that many infants who actually die from this,
- 24:40but there are quite a few in these outbreaks who become hospitalized and have
- 24:44prolonged hospitalizations.
- 24:46And then the other issue is even the older children who may not be at risk for apnea,
- 24:50the severity of this illness with a prolonged cough, treatment does not prevent
- 24:56that from happening unless you treat them in the very early stages where you
- 24:59may not be suspecting the infection.
- 25:02Treatment is mainly geared towards or mainly directed at, you know,
- 25:07trying to prevent transmission of infection. And if...
- 25:12Elderly grandparents are exposed, that could be a big problem too, right?
- 25:16Yeah, older people can have severe pretty much anything you give them.
- 25:21You know, they're going to be at risk potentially.
- 25:23You know, so you might have the younger, you know, healthier people in the middle,
- 25:27you know, transmitting, you know, just with, you know, cold and cough, not severe symptoms.
- 25:32And then other people have the sequelae.
- 25:36What about vaccination gaps? Are we seeing particular pockets of underimmunization
- 25:40contributing to the outbreak?
- 25:42I know a lot of our listeners and community pediatricians, it's so frustrating
- 25:46where so many people seem to be declining vaccinations these days.
- 25:51Yeah, I think, I mean, the data, I don't know about specifically for San Antonio
- 25:57per se in terms of like any kind of, and it would be really interesting to do an analysis about,
- 26:03you know, like where people are getting their information and who they're, you know,
- 26:08who exactly is making these decisions.
- 26:11Certainly older people who are not getting their boosters are at risk for transmitting
- 26:16when they're exposed to young children.
- 26:18So those grandparents you're talking about, if they're not getting,
- 26:20you know, they may be relatively immune to pertussis if they've had pertussis
- 26:25as a child or if they've had multiple vaccinations.
- 26:28But typically people are getting Tdap every 10 years, and I think they really
- 26:32should if they're going to be around young children.
- 26:35Women who decline the tdap in pregnancy
- 26:40when there are quite a few the uptake is not
- 26:43really that high in a lot of places they're putting their child at risk because
- 26:47we know that pertussis rates at least in the infant very young children range
- 26:52of age once that vaccine recommendation was instituted in around like 2011 over
- 26:58the next couple of years the rates in very young children went down.
- 27:01So that gap, sometimes, at least when it first was instituted,
- 27:06was really like a systems problem.
- 27:08The OBGYN might recommend it, but they weren't giving it as a point-of-care vaccine.
- 27:13And so I think that really having the pediatrician talk to the OBs in the community
- 27:18and make sure that we're really encouraging those mothers to make them understand
- 27:22that if they can help prevent pertussis by transmitting higher antibody levels,
- 27:28that's not really a lifetime thing,
- 27:31but it's protecting the infant at a very young age.
- 27:33And so I don't know, you know, what the demographics of and the decision-making
- 27:39processes of the women who are declining.
- 27:41And then among school-age children, it's funny because any vaccine you look
- 27:46at, the rates of vaccination, let's say in the high schoolers,
- 27:50the seventh graders, the vaccination rates among kindergartners are lower kind of across the board.
- 27:56And what does that mean? That means that those, you know, older children who
- 27:59are getting fewer vaccines, but they're also from, they were also in kindergarten
- 28:03several years ago, the messaging has gotten more, more intense and more
- 28:10sharing this information, you know, especially between parents,
- 28:14reading misinformation online, getting conflicting data from the government
- 28:19and getting suggestions from the government.
- 28:22COVID vaccine really led to a lot of mistrust.
- 28:26And whether, you know, whether any of that was warranted has really caused a big problem.
- 28:33So I think that it's the younger kids, the parents that are having children
- 28:37in the last few years tend to be our group that we need to be targeting for education.
- 28:44And as far as gaps, the data exists that certain schools have much,
- 28:50much lower rates of vaccination in San Antonio as well as other across the country.
- 28:56If you look, you can break down the data by school and it tends to be certain
- 29:00private schools in particular, although some public school districts have lower rates.
- 29:05And the very high rates of exemption in certain pockets in certain schools.
- 29:10And I think that that culture of catering to some of those parents and parents
- 29:17talking to each other and believing that vaccines aren't warranted,
- 29:21that vaccines aren't natural, that vaccines are harmful,
- 29:24that they really aren't necessary or that only some are necessary leads to these pockets.
- 29:29And it's very frustrating because the anti-vaccine movement And it is not,
- 29:33you know, I've been following this for a long, long time. It's just kind of gained steam.
- 29:37And now it's like extremely dispiriting.
- 29:42So much misinformation out there. A lot.
- 29:45And you've seen one patient with pertussis at University Hospital? I've seen one older kid.
- 29:53We've had other cases, but I've only had one in the last few weeks that I've
- 29:59seen specifically in the older child cohort.
- 30:03And this was a complex patient with multiple medical problems that the.
- 30:10Pertussis infection, you know, you can't really identify how much it was contributing
- 30:15to the other complications, but I really am concerned that that might have played a role.
- 30:20And that was not a vaccinated patient.
- 30:23So that was not a classic presentation. It was a patient who had like cough
- 30:28and congestion and fever, that type of thing, but was identified on respiratory
- 30:31viral testing, you know, the wide panel.
- 30:34So the other thing to comment is, you know, we have more and more of pertussis
- 30:37cases identified, some of this is really increased testing because we have these
- 30:43panels that, you know, didn't used to exist. You would have to do targeted testing.
- 30:48And, you know, I'm old enough to remember when, you know, PCR was kind of like,
- 30:52you know, the culture was the gold standard and culture takes a long time and
- 30:57it's less sensitive and it's hard to, you know, arrange.
- 31:00So we are identifying a lot of cases that we weren't identifying before.
- 31:03And so all of this needs to be taken into consideration when you look at total cases.
- 31:09Dina, this is all so insightful. Thank you so much for being here in the podcast
- 31:13studio and talking about this on such short notice.
- 31:18Is there anything else you want to say to pediatricians regarding flu or pertussis?
- 31:23I just want to keep emphasizing, like, keeping an eye on the numbers and knowing
- 31:29what's going on in the community and also when you, you know, for parent education,
- 31:36really try to, there's a lot of this shared decision-making going on that,
- 31:39you know, is kind of a newer concept. It's not that new, I guess.
- 31:42Really trying to understand where the parents are coming from,
- 31:45where they're getting their information.
- 31:47And then instead of being adversarial, you know, really just getting them.
- 31:52You know, the information that they need and reassuring them.
- 31:54And I, you know, from, you know, when I interact with pediatricians in the community,
- 31:58many of whom I know, they do a great job at this.
- 32:00They already do a great job at this. So I'm just here to commend them.
- 32:03And we have an episode on motivational interviewing where the doctor talks specifically
- 32:10about when you're talking to a patient, a family,
- 32:14a mom or dad or caregiver about vaccine hesitancy and how motivational interviewing
- 32:19can help with that. Absolutely.
- 32:22And how concerned are you just overall with flu and pertussis right now?
- 32:29I am, I think, well, the good thing about Pertussis is that the big outbreak
- 32:35that we started having in the fall last year, even though we have a lot of cases
- 32:38going on and Texas is having a surge, actually, we have more cases than last year.
- 32:43Nationally, we actually have a little bit of a decline in number of cases since last year.
- 32:49So, I mean, I think some of that is reassuring. I think the Texas part is a
- 32:54little frustrating, but, you know, it remains to be seen. I'm concerned.
- 33:00As far as influenza, I'm pretty concerned. Not so much that the vaccine mismatch
- 33:05is going to be such a problem,
- 33:06but more about vaccine uptake and the natural history of H3N2 disease,
- 33:12especially in the chronically ill or the kids who have complex medical needs,
- 33:17but also in healthy kids.
- 33:19So I'm just anticipating a rough winter.
- 33:23Wear a mask indoors in crowded settings.
- 33:27Sarah, do you advise that? I certainly, especially if you have any level of
- 33:31immunocompromise, if you're in crowds where you can't control your exposure,
- 33:35if you're on an airplane in particular, and in the hospital setting,
- 33:39really adhering to infection control recommendations.
- 33:41And I see sometimes when there's a patient who has a cough, but because,
- 33:45you know, they haven't been tested yet, maybe people aren't wearing a mask.
- 33:49In a clinic setting, it's hard to, where you aren't testing all the patients
- 33:54as opposed to hospital, a lot of people are not wearing masks when they come
- 33:56in the room. But really, children who have coughs or coughs and fever,
- 33:59you really should be protecting yourself as the clinician.
- 34:03And so I, you know, it's interesting to find out what people are doing in the
- 34:06community because I really recommend not getting sick from every single thing
- 34:10that you're exposed to. Put your mask on first.
- 34:12Yes, put your mask on first. And Dina, thank you so much.
- 34:16And are you doing anything fun for Thanksgiving, hopefully, as we're talking
- 34:19about all this not fun stuff to talk about?
- 34:24Well, I guess I'm going to go shopping after this and then I'm going to have, it's not fun.
- 34:29It's kind of fun to cook all day for a bunch of people and then clean.
- 34:33So kind of not fun. Are you having a big family gathering and are you doing the cooking?
- 34:38Yeah. My sister and I do all the cooking every year. We try to,
- 34:42you know, we get the kids to help some.
- 34:44You know, we have a big clan, so we're going to get them together and have kind
- 34:49of the traditional Thanksgiving dinner, whether they like it or not.
- 34:53And so you're going to shop and then start cooking.
- 34:56Yes. I haven't started doing anything yet. I haven't either.
- 34:59And I'm changing the recipes because they were more complicated than ones I picked out last week.
- 35:03And I'm shifting to just the easier recipes.
- 35:07Yeah. I started thinking. I was looking at some of these like New York Times
- 35:09things. Yes. I love this. Oh, I could make this. And then I was like,
- 35:12no, forget it. We're just going to make the normal stuff.
- 35:14Yes. I was looking at the New York Times one too. The squash pie.
- 35:17Oh, yeah. Where you could do like candied squash on the top and then. Oh, yeah.
- 35:21Yeah. I have all these grand aspirations.
- 35:24And then in the end, it's like, and then I told my youngest I was going to make
- 35:27the sweet potatoes in the little orange cups.
- 35:29And that did not go over well. I was like, absolutely not, Mom.
- 35:33So now from the New York Times, I'm going to make apple crumble.
- 35:36The headline said that it's much easier than making apple pie and it tastes just as good.
- 35:42That's a good idea. Maybe I will do that one if it's easier.
- 35:46Dr. Dina Sutter with University Health at UT Health San Antonio,
- 35:50our expert on infectious disease and pediatrics.
- 35:53Thank you for being here on Pediatrics Now. Thanks so much, Holly.