776-A Deep RNA Sequencing Atlas of Human Sensory Neurons

Paper Talk · Apr 11, 2026 · 26m

This study introduces a comprehensive transcriptomic atlas of human dorsal root ganglion (hDRG) neurons, which are essential for processing sensory information like touch, temperature, and pain. By utilizing laser capture microdissection and deep RNA sequencing on individual cell bodies, researchers successfully identified sixteen distinct neuronal types. The findings highlight significant evolutionary differences between human sensory cells and those of rodents, explaining why many pain treatments fail to translate from animal models to clinical practice. Through spatial transcriptomics and…