1617-Nur77 Agonism Enhances Natural Killer Cell Immunity
This research article investigates how the orphan nuclear receptor Nur77 serves as a vital transcriptional regulator that boosts Natural Killer (NK) cell immunity against hepatocellular carcinoma (HCC). By utilizing spatial and single-cell transcriptomics, the authors demonstrate that Nur77 expression correlates with improved patient survival and enhanced NK cell activation through AP-1 gene networks. The study reveals that a deficiency in this receptor impairs NK cell maturation and allows for faster tumor growth, whereas Nur77 agonism using the small molecule Cytosporone B restores…
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