1593-3D Epigenome of Glial Cell in Developing Human Cortex
This study presents a detailed three-dimensional epigenomic analysis of the developing human cortex, focusing on four essential glial cell types: vRG, oRG, OPC, and microglia. By integrating data on gene expression, chromatin accessibility, and DNA methylation, the researchers identified thousands of cell-type-specific regulatory elements that drive brain development. They utilized machine learning to prioritize genetic variants associated with schizophrenia and Alzheimer’s disease, successfully validating how specific risk alleles disrupt enhancer activity in vivo. Furthermore, the findings…
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