202-sosta: Structure-Based Analysis of Spatial Omics Data
The paper introduces a novel approach called structure-based analysis for processing spatial omics data, focusing on multicellular anatomical arrangements rather than just single cells. This methodology is implemented in sosta, an open-source Bioconductor package designed for the reconstruction, characterization, and comparison of these anatomical structures. The authors demonstrate sosta's utility through two case studies: quantifying structural changes during colorectal malignancy transformation and recovering anatomically relevant gene expression gradients in human tonsil germinal centers…
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