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0.5 mg "sic" vs 400 mg aspirin; compound unnamed; human stakes: potential psychedelic/antidepressant but unconfirmed
0.5 mg "sic" vs 400 mg aspirin; compound unnamed; human stakes: potential psychedelic/antidepressant but unconfirmed
A single line in a paper flagged with a Latin mark calls out an impossible dose: half a milligram - one-eightieth the weight of an aspirin - and that unexplained number has haunted six decades of research into a drug that made rodents act like they'd taken LSD. How did a molecule that produced clear psychedelic-like effects in animals, yet caused uncontrollable vomiting and produced no psychedelic reports in humans at 25 mg, remain a pharmacological ghost in the literature?
In…
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