635-The Medulloblastoma Metastatic Niche
This research explores how metastatic medulloblastoma survives in the nutrient-poor environment of the leptomeninges by actively altering its surroundings. The study reveals that cancer cells release PDGF ligands to recruit meningeal fibroblasts, which are then reprogrammed into a specialized, tumor-supporting state. These modified fibroblasts promote metastatic growth and colonization by signaling back to the tumor through bone morphogenetic proteins. By identifying this specific intercellular communication loop, the authors suggest that targeting the PDGF-receptor-α pathway could offer a…
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