801-Landscape of Structural Variation in Pediatric Cancer
This study in Cancer Cell provides a comprehensive structural variant (SV) map of pediatric cancer by analyzing genomes from 1,616 children and comparing them to adult data. Researchers discovered that while children generally have fewer genomic rearrangements in solid and brain tumors, their blood cancers exhibit a mutational burden similar to adults. A major finding identifies RAG-mediated mutagenesis as a primary driver of recurrent SV hotspots in pediatric leukemias, expanding our understanding of how these cancers initiate. The report also details how complex SVs, such as chromothripsis…
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