1497-Structural Principles of CNNM4 Magnesium Transport
The paper describe the discovery of a unique tetrameric structure in the human CNNM4 protein, a vital regulator of magnesium levels in the body. Unlike its bacterial relatives that form simple pairs, human CNNM4 assembles as a dimer of dimers, a complex architecture stabilized by the binding of MgATP. Researchers utilized cryoelectron microscopy to capture the transporter in distinct "outward-facing" and "occluded" states, revealing how the protein transitions to move ions across the cell membrane. A key finding is the identification of an intracellular acidic patch that acts as a sensor…
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