643-EMT and Cancer Stem Cells
This review examines the complex relationship between epithelial-mesenchymal transition (EMT) and the differentiation status of cells in both development and cancer. While EMT is traditionally viewed as a differentiation step in embryos, the authors argue it actually induces a transient dedifferentiation that allows cells to adopt new identities. In a pathological context, this process enables cancer cells to acquire stem-like properties, leading to increased self-renewal, drug resistance, and metastatic potential. The researchers suggest that EMT transcription factors, such as Snail and…
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