Pharma 61: Antifungal Therapy - Targeting a Near-Neighbour

Clinical Deep Dives · Feb 4, 2026 · 1m

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This episode explores antifungal agents as the pharmacology of narrow discrimination. Fungi are eukaryotes-biologically closer to us than bacteria-so effective therapy depends on exploiting small but crucial differences in cell membranes, cell walls, and replication machinery. We examine ergosterol synthesis and binding, cell wall β-glucan inhibition, n…