310-PD-1 Sustains High-Affinity T Stem Cells
This research article investigates the mechanism by which stem-like CD8+ T cells (TSL), which are critical precursors for sustained anti-tumor responses, maintain their progenitor state despite chronic antigen exposure. The authors demonstrate that, contrary to traditional views, the inhibitory PD-1 pathway plays a crucial role by providing a negative-feedback loop that finely tunes the T-cell receptor (TCR) signaling intensity. This attenuation allows TSL cells with the highest TCR affinity to continuously proliferate and self-renew within specialized antigen-presentation niches in the…
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